Phospho-PERK (Thr982) Polyclonal Antibody | Invitrogen PA5-37773 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-PERK (Thr982) Polyclonal Antibody

catalog :

PA5-37773

quantity :

100 uL

price :

US 454.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, rat

application :

immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 3

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; rat; loading ...; fig 4a	Yi S, Shi W, Zuo M, Wang S, Ma R, Bi H, et al. Endoplasmic Reticulum Stress Is Involved in Glucocorticoid-Induced Apoptosis in PC12 Cells. Anal Cell Pathol (Amst). 2021;2021:5565671 pubmed publisher
	Shen W, Wang B, Yao R, Goetzinger K, Wu S, Gao H, et al. Obesity impacts placental function through activation of p-IRE1a-XBP1s signaling. Front Cell Dev Biol. 2023;11:1023327 pubmed publisher
	Feng Y, Jin D, Sokol E, Reinhardt F, Miller D, Gupta P. Cancer-specific PERK signaling drives invasion and metastasis through CREB3L1. Nat Commun. 2017;8:1079 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Phospho-PERK (Thr982) Polyclonal Antibody

Catalog # :

PA5-37773

Quantity :

100 uL

Price :

US 454.00

Clonality :

Polyclonal

Purity :

Affinity chromatography

Host :

Rabbit

Reactivity :

Human

Applications :

Immunohistochemistry (Paraffin): 1:50-1:100

Species :

Human

Isotype :

IgG

Storage :

-20 C

Description :

EIF2AK3 (PERK) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein sythesis. In the case of EIF2AK3, signaling is initiated by misfolded proteins in the ER. Defects in EIF2AK3 are the cause of Wolcott-Rallison syndrome (WRS), also known as multiple epiphyseal dysplasia with early-onset diabetes mellitus. WRS is a rare autosomal recessive disorder, characterized by permanent neonatal or early infancy insulin-dependent diabetes and, at a later age, epiphyseal dysplasia, osteoporosis, growth retardation and other multisystem manifestations, such as hepatic and renal dysfunctions, mental retardation and cardiovascular abnormalities.

Immunogen :

Peptide sequence around phosphorylation site of threonine 982(A-R-H(p)-T-G) derived from Human PEK/PERK.

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1:50-1:100

Aliases :

2.7.11.1; AI427929; EIF2AK3; eukaryotic translation initiation factor 2 alpha kinase 3; eukaryotic translation initiation factor 2-alpha kinase 3; HsPEK; OTTHUMP00000207187; OTTHUMP00000207188; Pancreatic eIF2-alpha kinase; PEK; Perk; PRKR-like endoplasmic reticulum kinase; WRS

more info or order :

Invitrogen product webpage