HMGCR Polyclonal Antibody | Invitrogen PA5-37367 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

HMGCR Polyclonal Antibody

catalog :

PA5-37367

quantity :

100 uL

price :

US 514.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 11

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; loading ...; fig 2k	Yu H, Rimbert A, Palmer A, Toyohara T, Xia Y, Xia F, et al. GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis. Cell. 2019;179:1276-1288.e14 pubmed publisher
	Wang T, Soundararajan A, Rabinowitz J, Jaiswal A, OSBORNE T, Pattabiraman P. Identification of the novel role of sterol regulatory element binding proteins (SREBPs) in mechanotransduction and intraocular pressure regulation. FASEB J. 2023;37:e23248 pubmed publisher
	White Z, Sun Z, Sauge E, Cox D, Donen G, Pechkovsky D, et al. Limb-girdle muscular dystrophy type 2B causes HDL-C abnormalities in patients and statin-resistant muscle wasting in dysferlin-deficient mice. Skelet Muscle. 2022;12:25 pubmed publisher
	Khandker L, Jeffries M, Chang Y, Mather M, Evangelou A, Bourne J, et al. Cholesterol biosynthesis defines oligodendrocyte precursor heterogeneity between brain and spinal cord. Cell Rep. 2022;38:110423 pubmed publisher
	Bhat N, Narayanan A, Fathzadeh M, Kahn M, Zhang D, Goedeke L, et al. Dyrk1b promotes hepatic lipogenesis by bypassing canonical insulin signaling and directly activating mTORC2 in mice. J Clin Invest. 2022;132: pubmed publisher
	Ho W, Chang J, Lim K, Cazenave Gassiot A, Nguyen A, Foo J, et al. TDP-43 mediates SREBF2-regulated gene expression required for oligodendrocyte myelination. J Cell Biol. 2021;220: pubmed publisher
	Mohamed M, Mohd Nafi S, Jaafar H, Paiman N. A Retrospective Hospital-Based Study of HMGCR Expression in HER2 IHC 2+ and 3+ Breast Cancer. Asian Pac J Cancer Prev. 2021;22:2043-2047 pubmed publisher
	Nagarajan S, Paul Heng M, Krycer J, Fazakerley D, Sharland A, Hoy A. Lipid and glucose metabolism in hepatocyte cell lines and primary mouse hepatocytes: a comprehensive resource for in vitro studies of hepatic metabolism. Am J Physiol Endocrinol Metab. 2019;316:E578-E589 pubmed publisher
	Torres Adorno A, Vitrac H, Qi Y, Tan L, Levental K, Fan Y, et al. Eicosapentaenoic acid in combination with EPHA2 inhibition shows efficacy in preclinical models of triple-negative breast cancer by disrupting cellular cholesterol efflux. Oncogene. 2019;38:2135-2150 pubmed publisher
	Ishikawa T, Hosaka Y, Beckwitt C, Wells A, OLTVAI Z, Warita K. Concomitant attenuation of HMG-CoA reductase expression potentiates the cancer cell growth-inhibitory effect of statins and expands their efficacy in tumor cells with epithelial characteristics. Oncotarget. 2018;9:29304-29315 pubmed publisher
	Chen M, Zhang J, Sampieri K, Clohessy J, Méndez L, Gonzalez Billalabeitia E, et al. An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer. Nat Genet. 2018;50:206-218 pubmed publisher

product information

Product Type :

Antibody

Product Name :

HMGCR Polyclonal Antibody

Catalog # :

PA5-37367

Quantity :

100 uL

Price :

US 514.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: 1:50-1:200, Immunohistochemistry (Paraffin): 1:50-1:100, Western Blot: 1:1,000-1:4,000

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) is a key enzyme in the mevalonate pathway, which is critical for the biosynthesis of cholesterol and other isoprenoids. HMGCR catalyzes the conversion of HMG-CoA to mevalonate, a rate-limiting step in the production of cholesterol. Due to its central role in cholesterol synthesis, HMGCR is a primary target for statin drugs, which are used to lower cholesterol levels and reduce the risk of cardiovascular disease.

Immunogen :

Recombinant full length human HMGCR

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:50-1:200, Immunohistochemistry (Paraffin): 1:50-1:100, Western Blot: 1:1,000-1:4,000

Aliases :

3H3M; 3-hydroxy-3-methylglutaryl CoA reductase (NADPH); 3-hydroxy-3-methylglutaryl-CoA reductase; 3-hydroxy-3-methylglutaryl-Coenzyme A reductase; HMDH; HMG CoA reductase; HMG CoAR; HMG-CoA reductase; HMG-CoAR; HMGCR; hydroxymethylglutaryl-CoA reductase; LDLCQ3; MGC103269; Red

more info or order :

Invitrogen product webpage