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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Phospho-TrkB (Tyr516) Polyclonal Antibody
catalog :
PA5-36695
quantity :
100 uL
price :
US 514.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section
more info or order :
Invitrogen product webpage
citations: 6
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:1000; loading ...; fig 7a, 7c
El Chehadeh S, Han K, Kim D, Jang G, Bakhtiari S, Lim D, et al. SLITRK2 variants associated with neurodevelopmental disorders impair excitatory synaptic function and cognition in mice. Nat Commun. 2022;13:4112 pubmed publisher
Meng P, Zhang X, Liu T, Liu J, Luo Y, Xie M, et al. A whole transcriptome profiling analysis for antidepressant mechanism of Xiaoyaosan mediated synapse loss via BDNF/trkB/PI3K signal axis in CUMS rats. BMC Complement Med Ther. 2023;23:198 pubmed publisher
Zainullina L, Vakhitova Y, Lusta A, Gudasheva T, Seredenin S. Dimeric mimetic of BDNF loop 4 promotes survival of serum-deprived cell through TrkB-dependent apoptosis suppression. Sci Rep. 2021;11:7781 pubmed publisher
Zalewska T, Jaworska J, Sypecka J, Ziemka Nalecz M. Impact of a Histone Deacetylase Inhibitor-Trichostatin A on Neurogenesis after Hypoxia-Ischemia in Immature Rats. Int J Mol Sci. 2020;21: pubmed publisher
Jaworska J, Zalewska T, Sypecka J, Ziemka Nalecz M. Effect of the HDAC Inhibitor, Sodium Butyrate, on Neurogenesis in a Rat Model of Neonatal Hypoxia-Ischemia: Potential Mechanism of Action. Mol Neurobiol. 2019;: pubmed publisher
Diaz J, Abiola S, Kim N, Avaritt O, Flock D, Yu J, et al. Therapeutic Hypothermia Provides Variable Protection against Behavioral Deficits after Neonatal Hypoxia-Ischemia: A Potential Role for Brain-Derived Neurotrophic Factor. Dev Neurosci. 2017;39:257-272 pubmed publisher
product information
Product Type :
Antibody
Product Name :
Phospho-TrkB (Tyr516) Polyclonal Antibody
Catalog # :
PA5-36695
Quantity :
100 uL
Price :
US 514.00
Clonality :
Polyclonal
Purity :
Antigen affinity chromatography
Host :
Rabbit
Reactivity :
Human, Mouse, Rat
Applications :
Immunocytochemistry: 1:200, Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:500-1:1,000
Species :
Human, Mouse, Rat
Isotype :
IgG
Storage :
Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.
Description :
NTRK2 (TRKB) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system. NTRK2 is the receptor for brain-derived neurotrophic factor (BDNF). Together, NTRK2 and BDNF regulate both short-term synaptic functions and long-term potentiation of brain synapses. TrkB is involved in the development and maintenance of the nervous system. Moreover, Trk B is a tyrosine kinase gene highly related to Trk A. Trk B expression is confined to tissues within the central and peripheral nervous systems. The brain-derived neurotrophic factor (BDNF) and NT-3, but not NGF, can induce rapid phosphorylation on tyrosine of Trk B gp145, one of the receptors encoded by Trk B, although BDNF elicits a response at least two orders of magnitude greater than NT-3. TrkB is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signaling through TrkB leads to cell differentiation. Mutations in the TrkB gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for the TrkB gene.
Immunogen :
Synthetic phosphopeptide derived from human Trk B around the phosphorylation site of Tyrosine 516
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: 1:200, Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:500-1:1,000
Aliases :
AI848316; BDNF/NT-3 growth factors receptor; BDNF-tropomyosine receptor kinase B; C030027L06Rik; EC 2.7.10.1; GP145 TrkB; GP145TrkB; GP145-TrkB; GP145-TrkB/GP95-TrkB; GP95 TrkB; GP95-TrkB; hyperphagia; kinase TrkB; neural receptor protein-tyrosine kinase (trkB); neurotrophic receptor tyrosine kinase 2; neurotrophic tyrosine kinase receptor type 2; neurotrophic tyrosine kinase, receptor, type 2; neurotrophic tyrosine receptor kinase type 2; NTRK 2; Ntrk2; OTTHUMP00000021573; OTTHUMP00000021574; OTTHUMP00000021576; OTTHUMP00000021577; RATTRKB1; Tkrb; Trk B; TRKB; trk-B; trkB protein; trkB tyrosine kinase; TRKB1; Tropomyosin-related kinase B; tyrosine kinase receptor B
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA