ATP7A Polyclonal Antibody | Invitrogen PA5-36558 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

ATP7A Polyclonal Antibody

catalog :

PA5-36558

quantity :

100 uL

price :

US 481.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:1000; loading ...; fig 1a, 5a	Liao Y, Zhao J, Bulek K, Tang F, Chen X, Cai G, et al. Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis. Nat Commun. 2020;11:900 pubmed publisher

product information

Product Type :

Antibody

Product Name :

ATP7A Polyclonal Antibody

Catalog # :

PA5-36558

Quantity :

100 uL

Price :

US 481.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunohistochemistry (Paraffin): 1:50-1:200

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

ATP7A (also known as Copper-transporting ATPase 1) functions as a transmembrane copper-translocating P-type ATPase and plays a vital role in systemic copper absorption in the gut and copper reabsorption in the kidney. Polarized epithelial cells such as Madin-Darby canine kidney cells are a physiologically relevant model for systemic copper absorption and reabsorption in vivo. Although ATP7A is not detectable in most normal tissues, it is expressed in a considerable fraction of many common tumor types. Increased expression of ATP7A renders cells resistant to cisplatin and carboplatin. Mutations in the ATP7A gene result in Menkes disease, which is fatal in early childhood.

Immunogen :

Synthetic peptide corresponding to amino acids 620-670 of human ATP7A

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1:50-1:200

Aliases :

ATP 7A; ATP7A; ATPase copper transporting alpha; ATPase, Cu++ transporting, alpha polypeptide; copper pump 1; Copper-transporting ATPase 1; Cu++-transporting P-type ATPase; DSMAX; FLJ17790; MC 1; MC1; Menke; Menkes disease-associated protein; menkes disease-associated protein homolog; Menkes protein; Menkes syndrome; MK; MNK; OHS; OTTHUMP00000062077; SMAX3

more info or order :

Invitrogen product webpage