FOXC1/FOXC2 Polyclonal Antibody | Invitrogen PA5-36261 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

FOXC1/FOXC2 Polyclonal Antibody

catalog :

PA5-36261

quantity :

100 uL

price :

US 464.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

product information

Product Type :

Antibody

Product Name :

FOXC1/FOXC2 Polyclonal Antibody

Catalog # :

PA5-36261

Quantity :

100 uL

Price :

US 464.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: 1:50-1:200, Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:500-1:1,000

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

The forkhead transcription factor genes FOXC1 (Mf1) and FOXC2 (Mfh1) interact with the Notch signaling pathway and are required for the prepatterning of anterior and posterior domains in the presumptive somites through a putative Notch/Delta/Mesp regulatory loop. The genes have similar, dose-dependent functions, and compensate for each other in the early development of the heart, blood vessels and somites. Both FOXC1 and FOXC2 are expressed in the mesenchyme from which the ocular drainage structures derive. FOXC1 and FOXC2 also interact in kidney and heart development. Mutations in the FOXC1 gene result in Axenfeld-Rieger malformations of the anterior segment of the eye and lead to an increased susceptibility of glaucoma, including juvenile glaucoma. Functional regions in FOXC1 are required for nuclear localization and transcriptional regulation. Specifically, two regions in the FOXC1 forkhead domain, one rich in basic amino acid residues, and a second, highly conserved among all FOX proteins, are necessary for nuclear localization of the FOXC1 protein.

Immunogen :

Synthetic peptide corresponding to amino acids 100-150 of human FoxC1

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:50-1:200, Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:500-1:1,000

Aliases :

ARA; BF-3; Brain factor 3; ch; congenital hydrocephalus; Fkh1; fkh-1; Fkh14; FKHL14; FKHL7; forkhead box C1; forkhead box C1 protein; forkhead box C2; forkhead box C2 (MFH-1 mesenchyme forkhead 1); forkhead box C2 (MFH-1, mesenchyme forkhead 1); forkhead box protein C1; Forkhead box protein C2; forkhead homolog 14; forkhead, Drosophila, homolog-like 14; forkhead, drosophila, homolog-like 7; forkhead/winged helix-like transcription factor 7; forkhead-related activator 3; forkhead-related protein FKHL14; Forkhead-related protein FKHL7; forkhead-related transcription factor 3; Foxc1; Foxc2; FREAC3; FREAC-3; frkhda; Hfhbf3; HFH-BF-3; IGDA; IHG1; IRID1; LD; mesenchyme fork head protein 1; mesenchyme forkhead 1; mesoderm/mesenchyme forkhead 1; Mf1; MF-1; Mf4; MFH1; MFH-1; MFH-1 protein; MFH-1,mesenchyme forkhead 1; myeloid factor-delta; RIEG3; Transcription factor FKH-1; transcription factor FKH-14