PIGR Polyclonal Antibody | Invitrogen PA5-35340 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PIGR Polyclonal Antibody

catalog :

PA5-35340

quantity :

400 uL

price :

US 470.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

citations: 2

Reference
Biswas S, Mandal G, Payne K, Anadon C, Gatenbee C, Chaurio R, et al. IgA transcytosis and antigen recognition govern ovarian cancer immunity. Nature. 2021;591:464-470 pubmed publisher
Bhalla M, Hui Yeoh J, Lamneck C, Herring S, Tchalla E, Heinzinger L, et al. A1 adenosine receptor signaling reduces Streptococcus pneumoniae adherence to pulmonary epithelial cells by targeting expression of platelet-activating factor receptor. Cell Microbiol. 2020;22:e13141 pubmed publisher

product information

Product Type :

Antibody

Product Name :

PIGR Polyclonal Antibody

Catalog # :

PA5-35340

Quantity :

400 uL

Price :

US 470.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography, Protein A

Host :

Rabbit

Reactivity :

Human

Applications :

Flow Cytometry: 1:10-1:50, Immunocytochemistry: 1:10-1:50, Immunohistochemistry (Paraffin): 1:10-1:50, Western Blot: 1:1,000

Species :

Human

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Polymeric IgA and IgM is produced and secreted by B cells in the lamina propria, which is beneath the mucosal lining of polarized epithelial cells. Polymeric immunoglobulin receptors, also designated pIgRs, are expressed on the basolateral surface of glandular epithelia and mediate transcellular transport of secretory immunoglobulin polymers across the epithelium. pIgR associates with secreted dimeric IgA and IgM molecules. During transcellular transport of these Ig polymers, pIgR undergoes proteolytic cleavage to generate a fragment called secretory component (SC), polymeric immunoglobulin receptor or poly-IG receptor. When immunoglobulin polymers associate with SC, they become resistant to enzymatic degradation during the transcytosis process. SC and the pIgR are crucial for proper mucosal immunity where they represent a molecular chaperone for polymeric Igs to remain intact and enter into body fluids. The human SC (pIgR) gene maps to chromosome 1q31-q41 and encodes a 764 amino acid protein. The receptor contains five units with homology to the variable (V) units of immunoglobulins and a transmembrane region that shares homology to certain immunoglobulin variable regions.

Immunogen :

KLH conjugated synthetic peptide between 646-672 amino acids from the C-terminal region of human PIGR

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1:10-1:50, Immunocytochemistry: 1:10-1:50, Immunohistochemistry (Paraffin): 1:10-1:50, Western Blot: 1:1,000

Aliases :

hepatocellular carcinoma associated protein TB6; hepatocellular carcinoma-associated protein TB6; phosphatidylinositol glycan, class R; Pigr; Poly Ig receptor; poly-Ig receptor; polymeric immunoglobulin receptor; Secretory component; tb6