ATG5 Polyclonal Antibody | Invitrogen PA5-35201 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

ATG5 Polyclonal Antibody

catalog :

PA5-35201

quantity :

400 uL

price :

US 494.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunocytochemistry knockout validation

more info or order :

Invitrogen product webpage

citations: 4

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry knockout validation; mouse; 1:100; loading ...; fig s3	Huang Q, Liu Y, Zhang S, Yap Y, Li W, Zhang D, et al. Autophagy core protein ATG5 is required for elongating spermatid development, sperm individualization and normal fertility in male mice. Autophagy. 2021;17:1753-1767 pubmed publisher
	Cai M, Du B, Si Y, Miao J, Ge J, Zhang J, et al. Knockdown of VDAC1 alleviates the cognitive dysfunction secondary to sepsis-associated encephalopathy. Am J Transl Res. 2021;13:7538-7555 pubmed
	de Mascena Costa L, Debnath D, Harmon A, de Sousa Ara xfa jo S, da Silva Souza H, de Athayde Filho P, et al. Mechanistic studies of cytotoxic activity of the mesoionic compound MIH 2.4Bl in MCF-7 breast cancer cells. Oncol Lett. 2020;20:2291-2301 pubmed publisher
	Sunchu B, Riordan R, Yu Z, Almog I, Dimas Munoz J, Drake A, et al. Aggresome-Like Formation Promotes Resistance to Proteotoxicity in Cells from Long-Lived Species. J Gerontol A Biol Sci Med Sci. 2020;75:1439-1447 pubmed publisher

product information

Product Type :

Antibody

Product Name :

ATG5 Polyclonal Antibody

Catalog # :

PA5-35201

Quantity :

400 uL

Price :

US 494.00

Clonality :

Polyclonal

Purity :

Affinity chromatography, Antigen affinity chromatography, Protein A

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Immunocytochemistry: 1:200, Immunohistochemistry (Paraffin): 1:500, Western Blot: 1:1,000

Species :

Human, Mouse

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

ATG5 (Autophagy Related 5) is an important element for autophagy and may play an important role in the apoptotic process. ATG5 is also involved in other cellular processes that include mitochondrial quality control after oxidative damage, negative regulation of the innate anti-viral immune response, lymphocyte development and proliferation, MHC II antigen presentation, and adipocyte differentiation. Following conjugation to ATG12, the conjugate participates in the formation of autophagosome. ATG5 contributes to autophagic cell death by interacting with Fas-associated protein with death domain (FADD). The ATG5-ATG12 conjugate forms a cup-shaped isolation membrane that then detaches from the membrane immediately before or after autophagosome formation is completed. APG5 may play a role in the apoptotic process, possibly within the modified cytoskeleton. Further, APG5 expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. The APG5-APG12 conjugate also associates with innate immune response proteins such as RIG-I and VISA (also known as IPS-1), inhibiting type I interferon production and permitting viral replication in host cells. Diseases associated with ATG5 dysfunction include spinocerebellar ataxia.

Immunogen :

KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human ATG5

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:200, Immunohistochemistry (Paraffin): 1:500, Western Blot: 1:1,000

Aliases :

2010107M05Rik; 3110067M24Rik; APG 5; APG5; APG5 autophagy 5 like (APG5L); APG5 autophagy 5-like protein; APG5 autophagy 5-like protein, isoform 1; APG5L; APG5-LIKE; apoptosis-specific protein; Apoptosis-specific protein (ASP); ASP; atg5; Atg-5; ATG5 autophagy related 5 homolog; ATG5 autophagy related 5 homolog (S. cerevisiae); atg5.L; Atg5l; Atg5-PA; autophagy 5-like protein; autophagy protein 5; autophagy related 5; autophagy related 5 L homeolog; autophagy related 5-like protein; Autophagy-related 5; autophagy-specific gene 5; AW319544; C88337; CG1643; CG1643-PA; DmAtg5; Dmel CG1643; Dmel_CG1643; hAPG5; hypothetical protein LOC532686; LD34980p; Paddy; XELAEV_18027227mg; zgc:100934

more info or order :

Invitrogen product webpage