ATP2C1 Polyclonal Antibody | Invitrogen PA5-34757 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

ATP2C1 Polyclonal Antibody

catalog :

PA5-34757

quantity :

100 uL

price :

US 474.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot

product information

Product Type :

Antibody

Product Name :

ATP2C1 Polyclonal Antibody

Catalog # :

PA5-34757

Quantity :

100 uL

Price :

US 474.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human

Applications :

Western Blot: 1:500-1:3,000

Species :

Human

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

ATP2C1, also known as secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1, belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium from the cytosol to the Golgi lumen. Defects in this gene cause Hailey-Hailey disease, an autosomal dominant disorder characterized by persistent blisters and erosions of the skin. Unlike the related protein ATP2C2, ATP2C1 is ubiquitously expressed and displays a lower maximal turnover rate for overall Ca2+-ATPase reaction and a higher apparent affinity for cytosolic Ca2+ activation of phosphorylation. Recent evidence suggests that ATP2C1 is a key regulator of insulin-like growth factor receptor (IGF1R) processing in tumor progression in basal breast cancers.

Immunogen :

Recombinant fragment corresponding to a region within amino acids 483 and 761 of ATP2C1 (Uniprot ID#P98194)

Format :

Liquid

Applications w/Dilutions :

Western Blot: 1:500-1:3,000

Aliases :

1700121J11Rik; ATP2C1; ATP2C1A; ATPase 2C1; ATPase secretory pathway Ca2+ transporting 1; ATPase, Ca(2+)-sequestering; ATPase, Ca++ transporting, type 2C, member 1; ATPase, Ca++-sequestering; ATP-dependent Ca(2+) pump PMR1; AW061228; BCPM; calcium-transporting ATPase 2C1; calcium-transporting ATPase type 2C member 1; D930003G21Rik; HHD; hSPCA1; HUSSY 28; HUSSY-28; KIAA1347; Pmr1; PMR1L; rat; secretory pathway Ca(2+)-ATPase 1; secretory pathway Ca2+/Mn2+ ATPase 1; SPCA; SPCA1