Calnexin Polyclonal Antibody | Invitrogen PA5-34754 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Calnexin Polyclonal Antibody

catalog :

PA5-34754

quantity :

100 µL

price :

US 510.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, domestic sheep

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 13

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:1000; loading ...; fig s6d	Petkevicius K, Palmgren H, Glover M, Ahnmark A, Andr xe9 asson A, Madeyski Bengtson K, et al. TLCD1 and TLCD2 regulate cellular phosphatidylethanolamine composition and promote the progression of non-alcoholic steatohepatitis. Nat Commun. 2022;13:6020 pubmed publisher
	Pohl G, G xf6 z M, Gaertner A, Brodehl A, Cimen T, Saguner A, et al. Cardiomyopathy related desmocollin-2 prodomain variants affect the intracellular cadherin transport and processing. Front Cardiovasc Med. 2023;10:1127261 pubmed publisher
	Xu L, Zhang L, Xiang Y, Zhang X. Therapeutic role of adipose-derived mesenchymal stem cells-derived extracellular vesicles in rats with obstructive sleep apnea hypopnea syndrome. Regen Ther. 2023;22:210-223 pubmed publisher
	Scelsi H, Hill K, Barlow B, Martin M, Lieberman R. Quantitative differentiation of benign and misfolded glaucoma-causing myocilin variants on the basis of protein thermal stability. Dis Model Mech. 2023;16: pubmed publisher
	Lei R, Tan T, Hernandez Garcia A, Wang Y, Diefenbacher M, Teo C, et al. Prevalence and mechanisms of evolutionary contingency in human influenza H3N2 neuraminidase. Nat Commun. 2022;13:6443 pubmed publisher
	Zheng Y, Prince N, Peralta Marzal L, Ahmed S, Garssen J, Perez Pardo P, et al. The Autism Spectrum Disorder-Associated Bacterial Metabolite p-Cresol Derails the Neuroimmune Response of Microglial Cells Partially via Reduction of ADAM17 and ADAM10. Int J Mol Sci. 2022;23: pubmed publisher
	Intisar A, Shin H, Kim W, Kang H, Kim M, Kim Y, et al. Implantable Electroceutical Approach Improves Myelination by Restoring Membrane Integrity in a Mouse Model of Peripheral Demyelinating Neuropathy. Adv Sci (Weinh). 2022;9:e2201358 pubmed publisher
	Morante A, Baboolal D, Simon X, Pan E, Meneses P. Human Papillomavirus Minor Capsid Protein L2 Mediates Intracellular Trafficking into and Passage beyond the Endoplasmic Reticulum. Microbiol Spectr. 2022;10:e0150522 pubmed publisher
	Coukos R, Yao D, Sánchez M, Strand E, Olive M, Udeshi N, et al. An engineered transcriptional reporter of protein localization identifies regulators of mitochondrial and ER membrane protein trafficking in high-throughput CRISPRi screens. elife. 2021;10: pubmed publisher
	Birolini G, Valenza M, Di Paolo E, Vezzoli E, Talpo F, Maniezzi C, et al. Striatal infusion of cholesterol promotes dose-dependent behavioral benefits and exerts disease-modifying effects in Huntington's disease mice. EMBO Mol Med. 2020;12:e12519 pubmed publisher
	Ndiaye H, Liu J, Hall A, Minogue S, Morgan M, Waugh M. Immunohistochemical staining reveals differential expression of ACSL3 and ACSL4 in hepatocellular carcinoma and hepatic gastrointestinal metastases. Biosci Rep. 2020;40: pubmed publisher
	Liu P, Zhao L, Loos F, Marty C, Xie W, Martins I, et al. Immunosuppression by Mutated Calreticulin Released from Malignant Cells. Mol Cell. 2019;: pubmed publisher
	Young P, Senkal C, Suchanek A, Grevengoed T, Lin D, Zhao L, et al. Long-chain acyl-CoA synthetase 1 interacts with key proteins that activate and direct fatty acids into niche hepatic pathways. J Biol Chem. 2018;293:16724-16740 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Calnexin Polyclonal Antibody

Catalog # :

PA5-34754

Quantity :

100 µL

Price :

US 510.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Ovine, Rat

Applications :

Immunocytochemistry: 1:100-1:1,000, Immunohistochemistry (Paraffin): 1:100-1:1,000, Immunoprecipitation: 1:500-1:1,000, Western Blot: 1:5,000-1:20,000

Species :

Human, Mouse, Ovine, Rat

Isotype :

IgG

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Description :

Calnexin, also referred to as IP90, p88 and p90, is an approximately 90 kDa integral membrane protein of the endoplasmic reticulum (ER). Many resident ER proteins act as molecular chaperones and participate in the proper folding of polypeptides and their assembly into multisubunit proteins. Studies indicate that calnexin associates with the major histocompatibility complex (MHC) class I heavy chains, partial complexes of the T cell receptor and B cell membrane immunoglobulin, but not with completed receptor complexes. It has been shown that calnexin is a chaperone that retains incompletely or improperly folded proteins in the ER. The sequence Lys-Asp-Glu-Leu (KDEL) or a closely related sequence, is present at the carboxy-terminus of soluble ER resident proteins such as GRP78 and GRP94 and protein disulfide isomerase. Integral membrane ER resident proteins, like calnexin, often lack this KDEL sequence but contain positively charged cytosolic residues that ensure ER retention. Calnexin contains a large ER luminal domain (461 amino acids), a transmembrane segment (22 amino acids), and a cytoplasmic tail (89 amino acids).

Immunogen :

Synthetic peptide corresponding to a region within amino acids 525 and 592 of Calnexin (Uniprot ID#P27824)

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:100-1:1,000, Immunohistochemistry (Paraffin): 1:100-1:1,000, Immunoprecipitation: 1:500-1:1,000, Western Blot: 1:5,000-1:20,000

Aliases :

1110069N15Rik; AI988026; calmegin; calnexin; canx; canx-a; canx-b; clgn; clnx; cnx; D11Ertd153e; FLJ26570; hypothetical protein; IP90; Major histocompatibility complex class I antigen-binding protein p88; p88; P90; PP90; pp90 precursor

more info or order :

Invitrogen product webpage