mTOR Polyclonal Antibody | Invitrogen PA5-34663 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

mTOR Polyclonal Antibody

catalog :

PA5-34663

quantity :

100 µL

price :

US 496.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, proximity ligation assay

more info or order :

Invitrogen product webpage

citations: 15

Published Application/Species/Sample/Dilution	Reference
proximity ligation assay; human; loading ...; fig s7 western blot; human; loading ...; fig s4a	Wu X, Schneider N, Platen A, Mitra I, Blazek M, Zengerle R, et al. In situ characterization of the mTORC1 during adipogenesis of human adult stem cells on chip. Proc Natl Acad Sci U S A. 2016;113:E4143-50 pubmed publisher
	G xf6 bel T, Goebel B, Hyprath M, Lamminger I, Weisser H, Angioni C, et al. Three-dimensional growth reveals fine-tuning of 5-lipoxygenase by proliferative pathways in cancer. Life Sci Alliance. 2023;6: pubmed publisher
	Farini A, Tripodi L, Villa C, Napolitano F, Strati F, Molinaro D, et al. Inhibition of the immunoproteasome modulates innate immunity to ameliorate muscle pathology of dysferlin-deficient BlAJ mice. Cell Death Dis. 2022;13:975 pubmed publisher
	Anfimova P, Pankrasheva L, Moiseev K, Shirina E, Porseva V, Masliukov P. Ontogenetic Changes in the Expression of the Lin28 Protein in the Rat Hypothalamic Tuberal Nuclei. Int J Mol Sci. 2022;23: pubmed publisher
	Zhou B, Lei J, Wang Q, Qu T, Cha L, Zhan H, et al. LINC00960 regulates cell proliferation and glycolysis in pancreatic cancer through the miR-326-3p/TUFT1/AKT-mTOR axis. Kaohsiung J Med Sci. 2022;38:1155-1167 pubmed publisher
	Kelam N, Racetin A, Katsuyama Y, Vukojevi x107 K, Kosti x107 S. Immunohistochemical Expression Pattern of FGFR1, FGFR2, RIP5, and HIP2 in Developing and Postnatal Kidneys of Dab1-/- (yotari) Mice. Int J Mol Sci. 2022;23: pubmed publisher
	Liu Y, Wang Y, Yao D, Chen X, Zhang F, Feng Y, et al. Diane-35 and Metformin Induce Autophagy and Apoptosis in Polycystic Ovary Syndrome Women with Early-Stage Endometrial Carcinoma. Genes (Basel). 2022;13: pubmed publisher
	Chen B, Fluitt M, Brown A, Scott S, Gadicherla A, Ecelbarger C. Selective Deletion of the Mechanistic Target of Rapamycin From the Renal Collecting Duct Principal Cell in Mice Down-Regulates the Epithelial Sodium Channel. Front Physiol. 2021;12:787521 pubmed publisher
	Cheng L, Zhu X, Liu Y, Zhu K, Lin K, Li F. ACSL4 contributes to sevoflurane-induced ferroptotic neuronal death in SH-SY5Y cells via the 5' AMP-activated protein kinase/mammalian target of rapamycin pathway. Ann Transl Med. 2021;9:1454 pubmed publisher
	Li S, Qin C, Chen Y, Wei D, Tan Z, Meng J. Implications of cell division cycle associated 4 on the Wilm's tumor cells viability via AKT/mTOR signaling pathway. Ren Fail. 2021;43:1470-1478 pubmed publisher
	Paštar V, Lozić M, Kelam N, Filipović N, Bernard B, Katsuyama Y, et al. Connexin Expression Is Altered in Liver Development of Yotari (dab1 -/-) Mice. Int J Mol Sci. 2021;22: pubmed publisher
	Hermanowicz J, Pawlak K, Sieklucka B, Czarnomysy R, Kwiatkowska I, Kazberuk A, et al. MM-129 as a Novel Inhibitor Targeting PI3K/AKT/mTOR and PD-L1 in Colorectal Cancer. Cancers (Basel). 2021;13: pubmed publisher
	Hekman R, Hume A, Goel R, Abo K, Huang J, Blum B, et al. Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2. Mol Cell. 2020;80:1104-1122.e9 pubmed publisher
	Xu M, Gu M, Zhou J, Da J, Wang Z. Interaction of YAP1 and mTOR promotes bladder cancer progression. Int J Oncol. 2020;56:232-242 pubmed publisher
	Choi S, Titov A, Abboud G, Seay H, Brusko T, Roopenian D, et al. Inhibition of glucose metabolism selectively targets autoreactive follicular helper T cells. Nat Commun. 2018;9:4369 pubmed publisher

product information

Product Type :

Antibody

Product Name :

mTOR Polyclonal Antibody

Catalog # :

PA5-34663

Quantity :

100 µL

Price :

US 496.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

ChIP Assay: Assay-dependent, Immunocytochemistry: 1:100-1:1,000, Immunohistochemistry (Paraffin): 1:100-1:1,000, Immunoprecipitation: 1:100-1:500, Western Blot: 1:500-1:3,000

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Description :

FRAP1 (mTOR) is a serine/threonine kinase that plays a critical role in cellular growth and proliferation. Perturbations in the mTOR/PI3-kinase/AKT pathway are associated with numerous forms of cancer. FRAP1 is also the target of rapamycin and its analogues, which are currently used as immunosuppressants and cancer therapeutics. Mutations affecting the gene results in Smith-Kingsmore syndrome.

Immunogen :

Recombinant fragment corresponding to a region within amino acids 2386 and 2549 of mTOR (Uniprot ID#P42345)

Format :

Liquid

Applications w/Dilutions :

ChIP Assay: Assay-dependent, Immunocytochemistry: 1:100-1:1,000, Immunohistochemistry (Paraffin): 1:100-1:1,000, Immunoprecipitation: 1:100-1:500, Western Blot: 1:500-1:3,000

Aliases :

2610315D21Rik; AI327068; angiopoietin-like factor CDT6; FK506 binding protein 12-rapamycin associated protein 1; FK506 binding protein 12-rapamycin associated protein 2; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP12-rapamycin complex-associated protein; FKBP12-rapamycin complex-associated protein 1; FKBP-rapamycin associated protein; FKBP-rapamycin associated protein (FRAP); FKBP-rapamycin-associated protein FRAP; flat; FRAP; FRAP1; FRAP2; Mammalian target of rapamycin; mechanistic target of rapamycin; mechanistic target of rapamycin (serine/threonine kinase); mechanistic target of rapamycin kinase; Mtor; m-TOR; mTORC1; Raft1; Rapamycin and FKBP12 target 1; rapamycin and FKBP12 target-1 protein; rapamycin associated protein FRAP2; rapamycin target protein 1; RAPT1; serine/threonine-protein kinase mTOR; SKS

more info or order :

Invitrogen product webpage