CISD2 Polyclonal Antibody | Invitrogen PA5-34545 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CISD2 Polyclonal Antibody

catalog :

PA5-34545

quantity :

100 ug

price :

US 474.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

citations: 5

Reference
Kung W, Lin C, Chen W, Jiang L, Sun Y, Hsieh K, et al. Anti-Inflammatory CDGSH Iron-Sulfur Domain 2: A Biomarker of Central Nervous System Insult in Cellular, Animal Models and Patients. Biomedicines. 2022;10: pubmed publisher
Kung W, Lin C, Kuo C, Juin Y, Wu P, Lin M. Wild Bitter Melon Exerts Anti-Inflammatory Effects by Upregulating Injury-Attenuated CISD2 Expression following Spinal Cord Injury. Behav Neurol. 2020;2020:1080521 pubmed publisher
Lin M. CISD2 Attenuates Inflammation and Regulates Microglia Polarization in EOC Microglial Cells-As a Potential Therapeutic Target for Neurodegenerative Dementia. Front Aging Neurosci. 2020;12:260 pubmed publisher
Lin C, Chiang T, Sun Y, Lin M. Protective Effects of CISD2 and Influence of Curcumin on CISD2 Expression in Aged Animals and Inflammatory Cell Model. Nutrients. 2019;11: pubmed publisher
Rouzier C, Moore D, Delorme C, Lacas Gervais S, Ait El Mkadem S, Fragaki K, et al. A novel CISD2 mutation associated with a classical Wolfram syndrome phenotype alters Ca2+ homeostasis and ER-mitochondria interactions. Hum Mol Genet. 2017;26:1599-1611 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CISD2 Polyclonal Antibody

Catalog # :

PA5-34545

Quantity :

100 ug

Price :

US 474.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunohistochemistry: 2.5 ug/mL, Western Blot: 1-2 ug/mL

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

Maintain refrigerated at 2-8 C for up to 3 months. For long term storage store at -20 C

Description :

Defects in the CISD2 (CDGSH iron sulfur domain 2) gene are a cause of the neurodegenerative disorder Wolfram syndrome 2. CISD2 is a zinc finger protein that localizes to the endoplasmic reticulum and mitochondria and binds an iron/sulfur cluster. CISD2 interacts with Bcl-2 and can be displaced by the BH3-only protein BIK and contributes to the regulation of BIK-initiated autophagy. CISD2 deficiency in mice causes mitochondrial breakdown accompanied by autophagic cell death as well as the development of premature aging phenotype.

Immunogen :

A 15 amino acid peptide near the center of human CISD2

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry: 2.5 ug/mL, Western Blot: 1-2 ug/mL

Aliases :

1500009M05Rik; 1500026J14Rik; 1500031D15Rik; AI848398; B630006A20Rik; BcDNA:RE49709; CDGSH iron sulfur domain 2; CDGSH iron sulfur domain-containing protein 2; CDGSH iron-sulfur domain-containing protein 2; CDGSH iron-sulfur domain-containing protein 2 homolog; Cdgsh2; CG1458; CG1458-PA; cisd2; Cisd2-PA; dkey-162b23.1; Dmel CG1458; Dmel_CG1458; dWFS2; endoplasmic reticulum intermembrane small protein; ERIS; Miner1; MitoNEET; mitoNEET related 1; mitoNEET-related 1 protein; NAF-1; nervous system overexpressed protein 70; nervous system over-expressed protein 70; Noxp70; Nutrient-deprivation autophagy factor-1; RE49709p; RGD1566242; RH38554p; WFS2; Zcd2; zgc:64148; zgc:64148 protein; zinc finger, CDGSH-type domain 2; zKM0001