Pellino 1 Polyclonal Antibody | Invitrogen PA5-34465 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Pellino 1 Polyclonal Antibody

catalog :

PA5-34465

quantity :

100 ug

price :

US 464.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry

citations: 1

Reference
Guo M, Wang J, Zhao Y, Feng Y, Han S, Dong Q, et al. Microglial exosomes facilitate α-synuclein transmission in Parkinson's disease. Brain. 2020;143:1476-1497 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Pellino 1 Polyclonal Antibody

Catalog # :

PA5-34465

Quantity :

100 ug

Price :

US 464.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: 25 ug/mL, Western Blot: 1-2 ug/mL

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

Maintain refrigerated at 2-8 C for up to 3 months. For long term storage store at -20 C

Description :

The Pellino proteins are a highly homologous family of E3 ubiquitin ligases that act as upstream mediators in Toll-like receptor (TLR) pathways that lead to activation of MAP kinases and transcription factors. Pellino 1 is required for interleukin-1-mediated signaling through its interaction with the IRAK4-IRAK-TRAF6 complex, ultimately resulting in the activation of NF-Kappa-B. Like other members of the Pellino family, Pellino 1 is an E3 ubiquitin ligase, able to catalyze the polyubiquitination of IRAK1. It is activated via phosphorylation by either IRAK1 and IRAK4 or the IKK-related kinases IKK-epsilon; and TBK1. In addition to phosphorylation, Pellino 1 activity is also modulated via ubiquitination and sumoylation.

Immunogen :

A 15 amino acid peptide near the carboxy terminus of human Pellino 1

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 25 ug/mL, Western Blot: 1-2 ug/mL

Aliases :

2810468L03Rik; A930031K15Rik; AA409794; AI586297; D11Ertd676e; E3 ubiquitin-protein ligase pellino homolog 1; Peli1; pellino 1; pellino E3 ubiquitin protein ligase 1; pellino homolog 1; pellino1; pellino-1; Pellino-related intracellular-signaling molecule; PRISM; protein pellino homolog 1; RING-type E3 ubiquitin transferase pellino homolog 1