DELE Polyclonal Antibody | Invitrogen PA5-34403 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

DELE Polyclonal Antibody

catalog :

PA5-34403

quantity :

100 ug

price :

US 464.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, rat

application :

western blot, immunohistochemistry

more info or order :

Invitrogen product webpage

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:500; loading ...	Guo X, Aviles G, Liu Y, Tian R, Unger B, Lin Y, et al. Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway. Nature. 2020;579:427-432 pubmed publisher

product information

Product Type :

Antibody

Product Name :

DELE Polyclonal Antibody

Catalog # :

PA5-34403

Quantity :

100 ug

Price :

US 464.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Rat

Applications :

Immunohistochemistry: 20 ug/mL, Western Blot: 1 ug/mL

Species :

Human, Rat

Isotype :

IgG

Storage :

Maintain refrigerated at 2-8 C for up to 3 months. For long term storage store at -20 C

Description :

DELE is a recently identified DAP3-binding protein that is thought to be important in the induction of death receptor-mediated apoptosis. Transfected cells that stably express DELE were found to be susceptible to apoptosis induction by TNF-Alpha and TRAIL, whereas reducing DELE expression by siRNA rescued these cells from apoptosis induction. Furthermore, the reduction of DELE expression also inhibited the activation of caspase-3, caspase-8 and caspase-9 following stimulation by TNF-Alpha, anti-Fas, or TRAIL, indicating the importance of DELE in apoptosis mediated by death receptors.

Immunogen :

An 18 amino acid synthetic peptide near the amino terminus of human DELE

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry: 20 ug/mL, Western Blot: 1 ug/mL

Aliases :

0610009O20Rik; 2700004E22Rik; DAP3-binding cell death enhancer 1; Death ligand signal enhancer; Dele; Dele1; KIAA0141; RIKEN cDNA 0610009O20 gene

more info or order :

Invitrogen product webpage