TTYH2 Polyclonal Antibody | Invitrogen PA5-34395 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TTYH2 Polyclonal Antibody

catalog :

PA5-34395

quantity :

100 ug

price :

US 470.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

more info or order :

Invitrogen product webpage

citations: 2

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig s3g	Lu Q, Liu J, Zhao S, Gomez Castro M, Laurent Rolle M, Dong J, et al. SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2. Immunity. 2021;54:1304-1319.e9 pubmed publisher
	Bae Y, Kim A, Cho C, Kim D, Jung H, Kim S, et al. TTYH1 and TTYH2 Serve as LRRC8A-Independent Volume-Regulated Anion Channels in Cancer Cells. Cells. 2019;8: pubmed publisher

product information

Product Type :

Antibody

Product Name :

TTYH2 Polyclonal Antibody

Catalog # :

PA5-34395

Quantity :

100 ug

Price :

US 470.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunohistochemistry: 2.5 ug/mL, Western Blot: 1 ug/mL

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

Maintain refrigerated at 2-8 C for up to 3 months. For long term storage store at -20 C

Description :

TTYH2 is a member of the tweety family of proteins, a family of chloride anion channels containing five transmembrane regions. TTYH2 is a Ca2+-activated large conductance chloride (Cl-) channel and may play a role in kidney tumorigenesis. It is also upregulated in colon carcinoma and is thought to play a role in cell proliferation and call aggregation, suggesting that TTYH2 may play a role in regulating both proliferation and metastatic potentials of colorectal cancer. The ubiquitin-protein ligase Nedd4-2 binds to and ubiquitinates TTYH2, thereby regulating its cell surface expression and total cellular levels.

Immunogen :

A 14 amino acid synthetic peptide near the amino terminus of human TTYH2

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry: 2.5 ug/mL, Western Blot: 1 ug/mL

Aliases :

1110001A03Rik; C17orf29; hTTY2; mTTY2; Protein tweety homolog 2; RGD1562969; TTYH2; tweety family member 2; tweety homolog 2; tweety homolog 2 (Drosophila)

more info or order :

Invitrogen product webpage