This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
LPHN1 Polyclonal Antibody
catalog :
PA5-33903
quantity :
50 ug
price :
US 464.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
Chinese hamsters, human, mouse, rat, dogs, bovine, pigs , domestic rabbit
application :
immunohistochemistry, immunohistochemistry - paraffin section
product information
Product Type :
Antibody
Product Name :
LPHN1 Polyclonal Antibody
Catalog # :
PA5-33903
Quantity :
50 ug
Price :
US 464.00
Clonality :
Polyclonal
Purity :
Antigen affinity chromatography
Host :
Rabbit
Reactivity :
Bat, Bovine, Canine, Hamster, Human, Mouse, Non-human primate, Porcine, Rabbit, Rat
Applications :
Immunohistochemistry (Paraffin): 8 ug/mL
Species :
Bat, Bovine, Canine, Hamster, Human, Mouse, Non-human primate, Porcine, Rabbit, Rat
Isotype :
IgG
Storage :
Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.
Description :
Adgrl1 (Latrophilin-1) is a calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Adgrl1 is a receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization, and may be implicated in the regulation of exocytosis. The Adgrl1 gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Adgrl1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms of Adgrl1. Diseases associated with ADGRL1 include Dermatophytosis and Retinal Degeneration, Late-Onset, Autosomal Dominant.
Immunogen :
Synthetic 16 amino acid peptide from N-terminal extracellular domain of human LPHN1.
Format :
Liquid
Applications w/Dilutions :
Immunohistochemistry (Paraffin): 8 ug/mL
Aliases :
2900070I05Rik; ADGRL1; Adhesion G protein-coupled receptor L1; AI182398; calcium-independent alpha-latrotoxin receptor 1; Cirl; Cirl1; CIRL-1; CL1; CL1BA; CLIBA; KIAA0821; latrophilin 1; latrophilin-1; LEC2; Lectomedin-2; Lphh2; LPHN1; mKIAA0821
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA