BAI1 Polyclonal Antibody | Invitrogen PA5-33352 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

BAI1 Polyclonal Antibody

catalog :

PA5-33352

quantity :

50 ug

price :

US 464.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

Chinese hamsters, human, mouse, rat, chicken, bovine

application :

immunohistochemistry, immunohistochemistry - paraffin section

product information

Product Type :

Antibody

Product Name :

BAI1 Polyclonal Antibody

Catalog # :

PA5-33352

Quantity :

50 ug

Price :

US 464.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Bovine, Chicken, Hamster, Human, Mouse, Non-human primate, Rat

Applications :

Immunohistochemistry (Paraffin): 14 ug/mL

Species :

Bovine, Chicken, Hamster, Human, Mouse, Non-human primate, Rat

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Adgrb1 is a phosphatidylserine receptor that enhances the engulfment of apoptotic cells, likely to be a potent inhibitor of angiogenesis in brain, and may play a significant role as a mediator of the p53 signal in suppression of glioblastoma. Adgrb1 may function in cell adhesion and signal transduction in the brain. Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. As such, tumors obtain blood supply for their growth, are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. Adgrb1 contains at least one functional p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated Adgrb1 and BAI3, which have similar tissue specificities and structures, however only Adgrb1 is transcriptionally regulated by p53. Adgrb1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas. Diseases associated with ADGRB1 include Glioblastoma.

Immunogen :

Synthetic 16 amino acid peptide from C-terminus of human BAI1.

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 14 ug/mL

Aliases :

ADGRB1; Adhesion G protein-coupled receptor B1; B830018M07Rik; Bai1; brain-specific angiogenesis inhibitor 1; FLJ41988; GDAIF; mKIAA4089; R75078; Vasculostatin-120; Vasculostatin-40; Vstat120; Vstat40; Vstat-40