Clostridium tetani Tetanus Toxin Polyclonal Antibody | Invitrogen PA5-33146 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Clostridium tetani Tetanus Toxin Polyclonal Antibody

catalog :

PA5-33146

quantity :

1 mL

price :

US 470.00

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

application :

western blot, ELISA

product information

Product Type :

Antibody

Product Name :

Clostridium tetani Tetanus Toxin Polyclonal Antibody

Catalog # :

PA5-33146

Quantity :

1 mL

Price :

US 470.00

Clonality :

Polyclonal

Purity :

Affinity chromatography

Host :

Goat

Reactivity :

Bacteria

Applications :

ELISA: 1 ug/mL, Western Blot: 1:100-1:500

Species :

Bacteria

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Tetanus toxin is a neurotoxin produced by the vegetative spore of Clostridium tetani. The toxin causes tetanus, a disease that is characterised by prolonged contraction of skeletal muscle. World-wide, approximately 1 million cases of tetanus occurs annually, resulting in approximately 300,000 to 500,000 deaths, mostly in developing countries. The tetanus toxin has a molecular weight of approximately 150kDa and consists of a heavy chain (B-chain, 100kDa) and a light chain (A-chain, 50kDa) that are connected by a disulfide bond. The toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits the release of the neurotransmitters GABA and glycine by synaptobrevin-2. This results in overactivity in the muscle. The binding of the toxin to neurons is irreversible.

Immunogen :

Tetanus Exotoxin

Format :

Liquid

Applications w/Dilutions :

ELISA: 1 ug/mL, Western Blot: 1:100-1:500

Aliases :

C. tetani; Tetanus Toxin