This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
MCK10 Polyclonal Antibody
catalog :
PA5-32718
quantity :
50 ug
price :
US 464.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, dogs, bovine, pigs
application :
immunohistochemistry, immunohistochemistry - paraffin section
product information
Product Type :
Antibody
Product Name :
MCK10 Polyclonal Antibody
Catalog # :
PA5-32718
Quantity :
50 ug
Price :
US 464.00
Clonality :
Polyclonal
Purity :
Antigen affinity chromatography
Host :
Rabbit
Reactivity :
Bat, Bovine, Canine, Equine, Human, Non-human primate, Porcine
Applications :
Immunohistochemistry (Paraffin): 10-25 ug/mL
Species :
Bat, Bovine, Canine, Equine, Human, Non-human primate, Porcine
Isotype :
IgG
Storage :
Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.
Description :
DDR1 is a receptor tyrosine kinase activated by collagen and is reported to regulate adhesion, cell migration and other cellular processes. Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants.
Immunogen :
Synthetic 16 amino acid peptide from C-terminus of human DDR1.
Format :
Liquid
Applications w/Dilutions :
Immunohistochemistry (Paraffin): 10-25 ug/mL
Aliases :
6030432F18; AI323681; Cak; CD167; CD167 antigen-like family member A; CD167a; Cell adhesion kinase; DAAP-278B20.1; DDR; DDR1; DDR1d; discoidin domain receptor family, member 1; discoidin domain receptor tyrosine kinase 1; discoidin receptor tyrosine kinase; Drd1; Eddr1; Epithelial discoidin domain receptor 1; epithelial discoidin domain-containing receptor 1; HGK2; mammary carcinoma kinase 10; MCK10; MCK-10; Mpk6; NEP; neuroepithelial tyrosine kinase; neurotrophic tyrosine kinase receptor type 4; neurotrophic tyrosine kinase, receptor, type 4; NTRK4; protein-tyrosine kinase 3; Protein-tyrosine kinase 3A; Protein-tyrosine kinase MPK-6; protein-tyrosine kinase PTK-3; protein-tyrosine kinase RTK-6; PTK3; PTK3A; PTK3A protein tyrosine kinase 3A; PTK3D; RTK6; TRK E; TRKE; Tyrosine kinase DDR; tyrosine-protein kinase CAK
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com81 Wyman Street
Waltham, MA USA 02451
800-678-5599
headquarters: USA
questions and comments