ZPK Polyclonal Antibody | Invitrogen PA5-32173 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

ZPK Polyclonal Antibody

catalog :

PA5-32173

quantity :

100 uL

price :

US 470.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 6

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:500; loading ...; fig 2j	Cuddy S, Schinlever A, Dochnal S, Seegren P, Suzich J, Kundu P, et al. Neuronal hyperexcitability is a DLK-dependent trigger of herpes simplex virus reactivation that can be induced by IL-1. elife. 2020;9: pubmed publisher
	Lee B, Oh Y, Cho E, DiAntonio A, Cavalli V, Shin J, et al. FK506-binding protein-like and FK506-binding protein 8 regulate dual leucine zipper kinase degradation and neuronal responses to axon injury. J Biol Chem. 2022;298:101647 pubmed publisher
	Kim H, Lee J, Cho Y. PDK1 is a negative regulator of axon regeneration. Mol Brain. 2021;14:31 pubmed publisher
	Niu J, Sanders S, Jeong H, Holland S, Sun Y, Collura K, et al. Coupled Control of Distal Axon Integrity and Somal Responses to Axonal Damage by the Palmitoyl Acyltransferase ZDHHC17. Cell Rep. 2020;33:108365 pubmed publisher
	Goodwani S, Fernández C, Acton P, Buggia Prevot V, McReynolds M, Ma J, et al. Dual Leucine Zipper Kinase Is Constitutively Active in the Adult Mouse Brain and Has Both Stress-Induced and Homeostatic Functions. Int J Mol Sci. 2020;21: pubmed publisher
	Cliffe A, Arbuckle J, Vogel J, Geden M, Rothbart S, Cusack C, et al. Neuronal Stress Pathway Mediating a Histone Methyl/Phospho Switch Is Required for Herpes Simplex Virus Reactivation. Cell Host Microbe. 2015;18:649-58 pubmed publisher

product information

Product Type :

Antibody

Product Name :

ZPK Polyclonal Antibody

Catalog # :

PA5-32173

Quantity :

100 uL

Price :

US 470.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunohistochemistry (Frozen): 1:100-1:1,000, Immunohistochemistry (Paraffin): 1:100-1:1,000, Western Blot: 1:500-1:3,000

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

ZPK is a member of serine/threonine protein kinase family. This kinase contains a leucine-zipper domain, and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation.

Immunogen :

Recombinant protein fragment corresponding to a region within amino acids 400 and 888 of Mouse MAP3K12

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Frozen): 1:100-1:1,000, Immunohistochemistry (Paraffin): 1:100-1:1,000, Western Blot: 1:500-1:3,000

Aliases :

DLK; Dual leucine zipper bearing kinase; dual leucine zipper kinase; dual leucine zipper kinase DLK; leucine zipper protein kinase; leucine-zipper protein kinase; M3KC; MAP3K12; MAPK-upstream kinase; MEKK12; Mitogen activated protein kinase 12 (Zipper (leucine) protein kinase); mitogen activated protein kinase kinase kinase 12; mitogen-activated protein kinase kinase kinase 12; Mixed lineage kinase; MUK; PK; protein kinase MUK; zipper (leucine) protein kinase; Zpk; ZPKP1

more info or order :

Invitrogen product webpage