NEK2 Polyclonal Antibody | Invitrogen PA5-31259 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

NEK2 Polyclonal Antibody

catalog :

PA5-31259

quantity :

100 uL

price :

US 474.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 2

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human; fig 3e	Wang J, Cheng P, Pavlyukov M, Yu H, Zhang Z, Kim S, et al. Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase EZH2. J Clin Invest. 2017;127:3075-3089 pubmed publisher
	Zhang X, Huang X, Xu J, Li E, Lao M, Tang T, et al. NEK2 inhibition triggers anti-pancreatic cancer immunity by targeting PD-L1. Nat Commun. 2021;12:4536 pubmed publisher

product information

Product Type :

Antibody

Product Name :

NEK2 Polyclonal Antibody

Catalog # :

PA5-31259

Quantity :

100 uL

Price :

US 474.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human

Applications :

Immunocytochemistry: 1:100-1:1,000, Immunohistochemistry (Paraffin): 1:100-1:1,000, Western Blot: 1:500-1:3,000

Species :

Human

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

NEK2 is involved in cell cycle regulation and is essential for faithful chromosome segregation. NEK2 is a gene that encodes for a serine/threonine-protein kinase. This protein plays a crucial role in the regulation of mitosis and is primarily located in the centrosome. During the G1 phase, the protein is undetectable, but its levels progressively increase throughout the S phase, reaching their peak in late G2 phase. The gene has several alternatively spliced transcript variants that encode different isoforms with distinct C-termini. NEK2 is associated with several diseases, including Retinitis Pigmentosa 67 and Retinitis Pigmentosa.

Immunogen :

Recombinant protein fragment corresponding to a region within amino acids 185 and 349 of Human NEK2

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:100-1:1,000, Immunohistochemistry (Paraffin): 1:100-1:1,000, Western Blot: 1:500-1:3,000

Aliases :

AA617254; C77054; HSPK 21; HsPK21; NEK 2; NEK 2A; Nek2; Nek2 kinase; NEK2A; Never in mitosis A-related kinase 2; NIMA - related expressed kinase 2; NIMA (never in mitosis gene a)-related expressed kinase 2; NIMA (never in mitosis gene a)-related kinase 2; NIMA related kinase 2; nimA-like protein kinase 1; NIMA-related expressed kinase 2; NIMA-related kinase 2; nimA-related protein kinase 2; NLK 1; NLK1; PPP1R111; protein phosphatase 1, regulatory subunit 111; RP67; Serine/threonine-protein kinase Nek2

more info or order :

Invitrogen product webpage