PPAR delta Polyclonal Antibody | Invitrogen PA5-29678 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PPAR delta Polyclonal Antibody

catalog :

PA5-29678

quantity :

100 uL

price :

US 470.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

citations: 6

Reference
Koh J, Pataky M, Dasari S, Klaus K, Vuckovic I, Ruegsegger G, et al. Enhancement of anaerobic glycolysis - a role of PGC-1α4 in resistance exercise. Nat Commun. 2022;13:2324 pubmed publisher
Lee H, Ha T, Jung C, Nirmala F, Park S, Huh Y, et al. Mitochondrial dysfunction in skeletal muscle contributes to the development of acute insulin resistance in mice. J Cachexia Sarcopenia Muscle. 2021;12:1925-1939 pubmed publisher
Lai N, Fealy C, Kummitha C, Cabras S, Kirwan J, Hoppel C. Mitochondrial Utilization of Competing Fuels Is Altered in Insulin Resistant Skeletal Muscle of Non-obese Rats (Goto-Kakizaki). Front Physiol. 2020;11:677 pubmed publisher
Koh J, Hancock C, Han D, Holloszy J, Nair K, Dasari S. AMPK and PPARβ positive feedback loop regulates endurance exercise training-mediated GLUT4 expression in skeletal muscle. Am J Physiol Endocrinol Metab. 2019;316:E931-E939 pubmed publisher
Koh J, Hancock C, Terada S, Higashida K, Holloszy J, Han D. PPARÎ² Is Essential for Maintaining Normal Levels of PGC-1Î± and Mitochondria and for the Increase in Muscle Mitochondria Induced by Exercise. Cell Metab. 2017;25:1176-1185.e5 pubmed publisher
Rutz S, Kayagaki N, Phung Q, Eidenschenk C, Noubade R, Wang X, et al. Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells. Nature. 2015;518:417-21 pubmed publisher

product information

Product Type :

Antibody

Product Name :

PPAR delta Polyclonal Antibody

Catalog # :

PA5-29678

Quantity :

100 uL

Price :

US 470.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunohistochemistry (Paraffin): 1:100-1:1,000, Western Blot: 1:500-1:3,000

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation.

Immunogen :

Recombinant fragment corresponding to a region within amino acids 129 and 378 of Human PPAR delta

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1:100-1:1,000, Western Blot: 1:500-1:3,000

Aliases :

FAAR; MGC3931; Nr1c2; NUC1; NUC-1; NUCI; NUCII; nuclear hormone receptor; nuclear hormone receptor 1; Nuclear receptor subfamily 1 group C member 2; OTTHUMP00000016256; OTTHUMP00000016257; peroxisome proliferative activated receptor delta; peroxisome proliferator; peroxisome proliferator activated receptor; peroxisome proliferator activated receptor beta; peroxisome proliferator activated receptor delta; peroxisome proliferator activator receptor beta; peroxisome proliferator activator receptor delta; peroxisome proliferator activator receptor, delta; peroxisome proliferator-activated nuclear receptor beta/delta variant 2; Peroxisome proliferator-activated receptor beta; Peroxisome proliferator-activated receptor delta; PPAR[b]; PPARB; Pparb/d; PPARbeta; PPAR-beta; Ppard; PPARdelta; PPAR-delta; PPARdelta/beta