Arginase 1 Polyclonal Antibody | Invitrogen PA5-29645 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Arginase 1 Polyclonal Antibody

catalog :

PA5-29645

quantity :

100 uL

price :

US 470.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

citations: 36

Reference
Hu W, Zhang X, Liu Z, Yang J, Sheng H, Liu Z, et al. Spatiotemporal orchestration of macrophage activation trajectories by Vγ4 T cells during skin wound healing. iScience. 2024;27:109545 pubmed publisher
Mandakhbayar N, Ji Y, El Fiqi A, Patel K, Yoon D, Dashnyam K, et al. Double hits with bioactive nanozyme based on cobalt-doped nanoglass for acute and diabetic wound therapies through anti-inflammatory and pro-angiogenic functions. Bioact Mater. 2024;31:298-311 pubmed publisher
Kumar P, Laurence E, Crossman D, Assimos D, Murphy M, Mitchell T. Oxalate disrupts monocyte and macrophage cellular function via Interleukin-10 and mitochondrial reactive oxygen species (ROS) signaling. Redox Biol. 2023;67:102919 pubmed publisher
Zheng G, Harms A, Tail M, Zhang H, Nimmo A, Skutella T, et al. Effects of a neurokinin-1 receptor antagonist in the acute phase after thoracic spinal cord injury in a rat model. Front Mol Neurosci. 2023;16:1128545 pubmed publisher
Ben Amara H, Martinez D, Shah F, Loo A, Emanuelsson L, Norlindh B, et al. Magnesium implant degradation provides immunomodulatory and proangiogenic effects and attenuates peri-implant fibrosis in soft tissues. Bioact Mater. 2023;26:353-369 pubmed publisher
Tian P, Zhao L, Kim J, Li X, Liu C, Cui X, et al. Dual stimulus responsive borosilicate glass (BSG) scaffolds promote diabetic alveolar bone defectsrepair by modulating macrophage phenotype. Bioact Mater. 2023;26:231-248 pubmed publisher
Li J, Fu G, Wang Y, Bian M, Xu Y, Zhang L, et al. The polarization of microglia and infiltrated macrophages in the injured mice spinal cords: a dynamic analysis. Peerj. 2023;11:e14929 pubmed publisher
Smith J, Chen W, Shivapurkar N, Gerber M, Tucker R, Kallakury B, et al. Target-Specific Nanoparticle Polyplex Down-Regulates Mutant Kras to Prevent Pancreatic Carcinogenesis and Halt Tumor Progression. Int J Mol Sci. 2023;24: pubmed publisher
Wilkinson H, Reubinoff B, Shveiky D, Hardman M, Menachem Zidon O. Epithelial arginase-1 is a key mediator of age-associated delayed healing in vaginal injury. Front Endocrinol (Lausanne). 2022;13:927224 pubmed publisher
Khoja S, Liu X, Truong B, Nitzahn M, Lambert J, Eliav A, et al. Intermittent lipid nanoparticle mRNA administration prevents cortical dysmyelination associated with arginase deficiency. Mol Ther Nucleic Acids. 2022;28:859-874 pubmed publisher
Kumar P, Yang Z, Lever J, Ch xe1 vez M, Fatima H, Crossman D, et al. Hydroxyproline stimulates inflammation and reprograms macrophage signaling in a rat kidney stone model. Biochim Biophys Acta Mol Basis Dis. 2022;1868:166442 pubmed publisher
Cottler P, Kang H, Nash V, Salopek L, Bruce A, Spiller K, et al. Immunomodulation of Acellular Dermal Matrix Through Interleukin 4 Enhances Vascular Infiltration. Ann Plast Surg. 2022;88:S466-S472 pubmed publisher
Kung W, Lin C, Chen W, Jiang L, Sun Y, Hsieh K, et al. Anti-Inflammatory CDGSH Iron-Sulfur Domain 2: A Biomarker of Central Nervous System Insult in Cellular, Animal Models and Patients. Biomedicines. 2022;10: pubmed publisher
Xue M, Sheng W, Song X, Shi Y, Geng Z, Shen L, et al. Atractylenolide III ameliorates spinal cord injury in rats by modulating microglial/macrophage polarization. CNS Neurosci Ther. 2022;28:1059-1071 pubmed publisher
Huang X, Yang Q, Xie L, Lei S. Histone methyltransferase enhancer of zeste 2 polycomb repressive complex 2 subunit exacerbates inflammation in depression rats by modulating microglia polarization. Bioengineered. 2022;13:5509-5524 pubmed publisher
Malchiodi Z, Cao H, Gay M, Safronenka A, Bansal S, Tucker R, et al. Cholecystokinin Receptor Antagonist Improves Efficacy of Chemotherapy in Murine Models of Pancreatic Cancer by Altering the Tumor Microenvironment. Cancers (Basel). 2021;13: pubmed publisher
Chang Y, Li J, Mirhaidari G, Zbinden J, Barker J, Blum K, et al. Zoledronate alters natural progression of tissue-engineered vascular grafts. FASEB J. 2021;35:e21849 pubmed publisher
Smith J, Cao H, Chen W, Kallakury B, Phillips T, Sutton L, et al. Vaccination with Polyclonal Antibody Stimulator (PAS) Prevents Pancreatic Carcinogenesis in the KRAS Mouse Model. Cancer Prev Res (Phila). 2021;14:933-944 pubmed publisher
Li M, McGhee E, Shinno L, Lee K, Lin Y. Exposure to Microbial Metabolite Butyrate Prolongs the Survival Time and Changes the Growth Pattern of Human Papillomavirus 16 E6/E7-Immortalized Keratinocytes in Vivo. Am J Pathol. 2021;191:1822-1836 pubmed publisher
de Melo G, Lazarini F, Larrous F, Feige L, Kornobis E, Levallois S, et al. Attenuation of clinical and immunological outcomes during SARS-CoV-2 infection by ivermectin. EMBO Mol Med. 2021;13:e14122 pubmed publisher
Song J, Frieler R, Vigil T, Ma J, Brombacher F, Goonewardena S, et al. Inactivation of Interleukin-4 Receptor α Signaling in Myeloid Cells Protects Mice From Angiotensin II/High Salt-Induced Cardiovascular Dysfunction Through Suppression of Fibrotic Remodeling. J Am Heart Assoc. 2021;10:e017329 pubmed publisher
Chen J, Chen Y, Shi Y, Ding S, Shen L, Wang R, et al. VX-765 reduces neuroinflammation after spinal cord injury in mice. Neural Regen Res. 2021;16:1836-1847 pubmed publisher
Na L, Wang S, Liu T, Zhang L. Ultrashort Wave Combined with Human Umbilical Cord Mesenchymal Stem Cell (HUC-MSC) Transplantation Inhibits NLRP3 Inflammasome and Improves Spinal Cord Injury via MK2/TTP Signalling Pathway. Biomed Res Int. 2020;2020:3021750 pubmed publisher
Liu X, Guo A, Tu Y, Li W, Li L, Liu W, et al. Fruquintinib inhibits VEGF/VEGFR2 axis of choroidal endothelial cells and M1-type macrophages to protect against mouse laser-induced choroidal neovascularization. Cell Death Dis. 2020;11:1016 pubmed publisher
Pavlovic N, Kopsida M, Gerwins P, Heindryckx F. Inhibiting P2Y12 in Macrophages Induces Endoplasmic Reticulum Stress and Promotes an Anti-Tumoral Phenotype. Int J Mol Sci. 2020;21: pubmed publisher
Lin M. CISD2 Attenuates Inflammation and Regulates Microglia Polarization in EOC Microglial Cells-As a Potential Therapeutic Target for Neurodegenerative Dementia. Front Aging Neurosci. 2020;12:260 pubmed publisher
Chen Y, Wang S, Shi Y, Chen J, Ding S, Tang J, et al. CRID3, a blocker of apoptosis associated speck like protein containing a card, ameliorates murine spinal cord injury by improving local immune microenvironment. J Neuroinflammation. 2020;17:255 pubmed publisher
Gelsomino L, Naimo G, Malivindi R, Augimeri G, Panza S, Giordano C, et al. Knockdown of Leptin Receptor Affects Macrophage Phenotype in the Tumor Microenvironment Inhibiting Breast Cancer Growth and Progression. Cancers (Basel). 2020;12: pubmed publisher
Perrotta P, Van der Veken B, Van der Veken P, Pintelon I, Roosens L, Adriaenssens E, et al. Partial Inhibition of Glycolysis Reduces Atherogenesis Independent of Intraplaque Neovascularization in Mice. Arterioscler Thromb Vasc Biol. 2020;40:1168-1181 pubmed publisher
Xu Y, Xu Y, Zhu Y, Sun H, Juguilon C, Li F, et al. Macrophage miR-34a Is a Key Regulator of Cholesterol Efflux and Atherosclerosis. Mol Ther. 2020;28:202-216 pubmed publisher
Park G, Kwon Y, Lee T, Kwon S, Ko H, Kim M, et al. Formyl Peptide Receptor 2 Activation Ameliorates Dermal Fibrosis and Inflammation in Bleomycin-Induced Scleroderma. Front Immunol. 2019;10:2095 pubmed publisher
Osborne N, Sundseth R, Gay M, Cao H, Tucker R, Nadella S, et al. Vaccine against gastrin, a polyclonal antibody stimulator, decreases pancreatic cancer metastases. Am J Physiol Gastrointest Liver Physiol. 2019;317:G682-G693 pubmed publisher
Hua F, Tian Y, Gao Y, Li C, Liu X. Colony‑stimulating factor 1 receptor inhibition blocks macrophage infiltration and endometrial cancer cell proliferation. Mol Med Rep. 2019;19:3139-3147 pubmed publisher
Grey Z, Howie R, Durham E, Hall S, Helke K, Steed M, et al. Sub-clinical dose of bone morphogenetic protein-2 does not precipitate rampant, sustained inflammatory response in bone wound healing. Wound Repair Regen. 2019;27:335-344 pubmed publisher
Colson C, Ghandour R, Dufies O, Rekima S, Loubat A, Munro P, et al. Diet Supplementation in ω3 Polyunsaturated Fatty Acid Favors an Anti-Inflammatory Basal Environment in Mouse Adipose Tissue. Nutrients. 2019;11: pubmed publisher
Song J, Kang H, Hong J, Kim C, Shim J, Lee C, et al. Umbilical cord-derived mesenchymal stem cell extracts reduce colitis in mice by re-polarizing intestinal macrophages. Sci Rep. 2017;7:9412 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Arginase 1 Polyclonal Antibody

Catalog # :

PA5-29645

Quantity :

100 uL

Price :

US 470.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

ELISA: 1:1,000-1:10,000, Immunocytochemistry: Assay-dependent, Immunohistochemistry (Paraffin): 1:100-1:1,000, Western Blot: 1:5,000-1:20,000

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Arginase-1 (Arg1) is a 35 kDa enzyme converting L-arginine to urea and L-ornithine, which is the final step in the urea cycle. The resulting polyamines are important for cell proliferation and removal of toxins that arise from protein degradation. By degrading arginine, Arginase 1 deprives NO synthase of its substrate and down-regulates nitric oxide production. In both human and mouse, Arginase 1 is expressed in the liver, neutrophils, myeloid derived suppressor cells (MDSC) and neural stem cells. In human, expression in blood neutrophils but not in CCR3+ granulocytes has been reported. In mice, expression of Arginase 1 is one of the hallmarks of alternatively activated macrophages (M2a). Arginase-1 may be expressed in the myeloid cells infiltrating tumors, and is typically found in the majority of hepatocellular carcinomas. Defects in Arginase 1 are the cause of argininemia, an autosomal recessive disorder characterized by hyperammonemia.

Immunogen :

Recombinant fragment corresponding to a region within amino acids 1 and 175 of Human Arginase I

Format :

Liquid

Applications w/Dilutions :

ELISA: 1:1,000-1:10,000, Immunocytochemistry: Assay-dependent, Immunohistochemistry (Paraffin): 1:100-1:1,000, Western Blot: 1:5,000-1:20,000

Aliases :

AI; A-I; AI type I arginase; AI256583; Arg1; Arg-1; Arginase; arginase 1; arginase 1 liver; arginase 1, liver; arginase I; arginase, liver; Arginase1; arginase-1; HGNC:663; Liver Arginase; Liver-type arginase; PGIF; similar to arginase, type I; Type 1 Arginase; type I arginase