SP1 Polyclonal Antibody | Invitrogen PA5-29165 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

SP1 Polyclonal Antibody

catalog :

PA5-29165

quantity :

100 uL

price :

US 514.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

citations: 13

Reference
El Mayet F, Jones C. Specificity protein 1 (Sp1) and glucocorticoid receptor (GR) stimulate bovine alphaherpesvirus 1 (BoHV-1) replication and cooperatively transactivate the immediate early transcription unit 1 promoter. J Virol. 2024;98:e0143623 pubmed publisher
Eni Aganga I, Lanaghan Z, Ismail F, Korolkova O, Goodwin J, Balasubramaniam M, et al. KLF6 activates Sp1-mediated prolidase transcription during TGF-β1 signaling. J Biol Chem. 2023;300:105605 pubmed publisher
Cheng Y, Chen Y, Lin C, Lieu A, Tsai H, Kwan A. High expression of GSKIP is associated with poor prognosis in meningioma. Medicine (Baltimore). 2022;101:e32209 pubmed publisher
Niu C, Li M, Chen Y, Zhang X, Zhu S, Zhou X, et al. LncRNA NCAL1 potentiates natural killer cell cytotoxicity through the Gab2-PI3K-AKT pathway. Front Immunol. 2022;13:970195 pubmed publisher
Hervouet K, Ferri xe9 M, Ankavay M, Montpellier C, Camuzet C, Alexandre V, et al. An Arginine-Rich Motif in the ORF2 capsid protein regulates the hepatitis E virus lifecycle and interactions with the host cell. PLoS Pathog. 2022;18:e1010798 pubmed publisher
Ganther S, Radaic A, Malone E, Kamarajan P, Chang N, Tafolla C, et al. Treponema denticola dentilisin triggered TLR2/MyD88 activation upregulates a tissue destructive program involving MMPs via Sp1 in human oral cells. PLoS Pathog. 2021;17:e1009311 pubmed publisher
Ledet R, Ruff S, Wang Y, Nayak S, Schneider J, Ueberheide B, et al. Identification of PIM1 substrates reveals a role for NDRG1 phosphorylation in prostate cancer cellular migration and invasion. Commun Biol. 2021;4:36 pubmed publisher
Krause C, Geißler C, Tackenberg H, El Gammal A, Wolter S, Spranger J, et al. Multi-layered epigenetic regulation of IRS2 expression in the liver of obese individuals with type 2 diabetes. Diabetologia. 2020;63:2182-2193 pubmed publisher
Schlag K, Steinhilber D, Karas M, Sorg B. Analysis of proximal ALOX5 promoter binding proteins by quantitative proteomics. FEBS J. 2020;287:4481-4499 pubmed publisher
Li Y, Feng D, Wang Z, Zhao Y, Sun R, Tian D, et al. Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion. Cell Death Differ. 2019;: pubmed publisher
Long J, Liao G, Wang Y, Tang D. Specific protein 1, c-Abl and ERK1/2 form a regulatory loop. J Cell Sci. 2019;132: pubmed publisher
Niu C, Li M, Zhu S, Chen Y, Zhou L, Xu D, et al. Decitabine Inhibits Gamma Delta T Cell Cytotoxicity by Promoting KIR2DL2/3 Expression. Front Immunol. 2018;9:617 pubmed publisher
Briggs E, Ha S, Mita P, Brittingham G, Sciamanna I, Spadafora C, et al. Long interspersed nuclear element-1 expression and retrotransposition in prostate cancer cells. Mob DNA. 2018;9:1 pubmed publisher

product information

Product Type :

Antibody

Product Name :

SP1 Polyclonal Antibody

Catalog # :

PA5-29165

Quantity :

100 uL

Price :

US 514.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human

Applications :

ChIP Assay: Assay-Dependent, Immunocytochemistry: 1:100-1:1,000, Immunohistochemistry (Paraffin): 1:100-1:1,000, Immunoprecipitation: 1:100-1:500, Western Blot: 1:500-1:3,000

Species :

Human

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

SP1 is a transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression.

Immunogen :

Recombinant fragment corresponding to a region within amino acids 18 and 303 of Human SP1

Format :

Liquid

Applications w/Dilutions :

ChIP Assay: Assay-Dependent, Immunocytochemistry: 1:100-1:1,000, Immunohistochemistry (Paraffin): 1:100-1:1,000, Immunoprecipitation: 1:100-1:500, Western Blot: 1:500-1:3,000

Aliases :

1110003E12Rik; AA450830; AI845540; HGNC:11205; SP1; Sp1 transcription factor; Sp1-1; specificity protein 1; trans-acting transcription factor 1; transcription factor Sp1; TSFP1