ZO-1 Polyclonal Antibody | Invitrogen PA5-28858 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

ZO-1 Polyclonal Antibody

catalog :

PA5-28858

quantity :

100 uL

price :

US 494.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, bovine

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

citations: 9

Reference
Hasan M, Chen J, Wang H, Du Y, Clayton Y, Gu L, et al. Glycine-β-Muricholic Acid Improves Liver Fibrosis and Gut Barrier Function by Reducing Bile Acid Pool Size and Hydrophobicity in Male Cyp2c70 Knockout Mice. Cells. 2023;12: pubmed publisher
Andrani M, Borghetti P, Ravanetti F, Cavalli V, Ferrari L, De Angelis E, et al. Acetate and propionate effects in response to LPS in a porcine intestinal co-culture model. Porcine Health Manag. 2023;9:23 pubmed publisher
Hasan M, Chen J, Matye D, Wang H, Luo W, Gu L, et al. Combining ASBT inhibitor and FGF15 treatments enhances therapeutic efficacy against cholangiopathy in female but not male Cyp2c70 KO mice. J Lipid Res. 2023;64:100340 pubmed publisher
Kobutree P, Tothonglor A, Roumwong A, Jindatip D, Agthong S. Curcumin reduces blood-nerve barrier abnormalities and cytotoxicity to endothelial cells and pericytes induced by cisplatin. Folia Morphol (Warsz). 2022;: pubmed publisher
Yu W, Ye T, Ding J, Huang Y, Peng Y, Xia Q, et al. miR-4456/CCL3/CCR5 Pathway in the Pathogenesis of Tight Junction Impairment in Chronic Obstructive Pulmonary Disease. Front Pharmacol. 2021;12:551839 pubmed publisher
Gunasekaran A, Eckert J, Burge K, Zheng W, Yu Z, Kessler S, et al. Hyaluronan 35 kDa enhances epithelial barrier function and protects against the development of murine necrotizing enterocolitis. Pediatr Res. 2020;87:1177-1184 pubmed publisher
Dong J, Zheng Y, Wu T, He Q, Teng G, Wang H. Protective effect of Saccharomyces boulardii on intestinal mucosal barrier of dextran sodium sulfate-induced colitis in mice. Chin Med J (Engl). 2019;132:1951-1958 pubmed publisher
Yang S, Gu C, Mandeville E, Dong Y, Esposito E, Zhang Y, et al. Anesthesia and Surgery Impair Blood-Brain Barrier and Cognitive Function in Mice. Front Immunol. 2017;8:902 pubmed publisher
Kistler W, Baas D, Lemeille S, Paschaki M, Seguín Estévez Q, Barras E, et al. RFX2 Is a Major Transcriptional Regulator of Spermiogenesis. PLoS Genet. 2015;11:e1005368 pubmed publisher

product information

Product Type :

Antibody

Product Name :

ZO-1 Polyclonal Antibody

Catalog # :

PA5-28858

Quantity :

100 uL

Price :

US 494.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Bovine, Human, Mouse

Applications :

Immunocytochemistry: Assay-dependent, Immunohistochemistry (Frozen): Assay-dependent, Immunohistochemistry (Paraffin): 1:100-1:1,000, Western Blot: 1:500-1:3,000

Species :

Bovine, Human, Mouse

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

ZO-1 forms complexes with either ZO-2 or ZO-3. In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. ZO-1 expression is significantly reduced in many breast cancer lines. ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue. ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. ZO-1 may be involved in signal transduction at cell-cell junctions. Two transcript variants encoding distinct isoforms have been identified for the ZO-1 gene. Diseases associated with ZO-1 dysfunction include Celiac Disease and Congenital Nephrotic Syndrome.

Immunogen :

Recombinant fragment corresponding to a region within amino acids 373 and 615 of Human ZO-1

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: Assay-dependent, Immunohistochemistry (Frozen): Assay-dependent, Immunohistochemistry (Paraffin): 1:100-1:1,000, Western Blot: 1:500-1:3,000

Aliases :

DKFZp686M05161; I79_005485; MGC133289; OTTHUMP00000174520; Tight junction protein 1; tight junction protein 1 (zona occludens 1); tight junction protein ZO-1; Tjp1; zo1; ZO-1; ZO-1 MDCK; zona occludens 1; zona occludens protein 1; zonula occludens 1; zonula occludens 1 protein; zonula occludens protein 1