C16orf62 Polyclonal Antibody | Invitrogen PA5-28553 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

C16orf62 Polyclonal Antibody

catalog :

PA5-28553

quantity :

100 uL

price :

US 470.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

citations: 6

Reference
Singla A, Chen Q, Suzuki K, Song J, Fedoseienko A, Wijers M, et al. Regulation of murine copper homeostasis by members of the COMMD protein family. Dis Model Mech. 2021;14: pubmed publisher
Pim D, Broniarczyk J, Siddiqa A, Massimi P, Banks L. Human Papillomavirus 16 L2 Recruits both Retromer and Retriever Complexes during Retrograde Trafficking of the Viral Genome to the Cell Nucleus. J Virol. 2021;95: pubmed publisher
Evans A, Daly J, Anuar A, Simonetti B, Cullen P. Acute inactivation of retromer and ESCPE-1 leads to time-resolved defects in endosomal cargo sorting. J Cell Sci. 2020;133: pubmed publisher
Ben Shlomo S, Mouhadeb O, Cohen K, Varol C, Gluck N. COMMD10-Guided Phagolysosomal Maturation Promotes Clearance of Staphylococcus aureus in Macrophages. iScience. 2019;14:147-163 pubmed publisher
McNally K, Faulkner R, Steinberg F, Gallon M, Ghai R, Pim D, et al. Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling. Nat Cell Biol. 2017;19:1214-1225 pubmed publisher
Phillips Krawczak C, Singla A, Starokadomskyy P, Deng Z, Osborne D, Li H, et al. COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A. Mol Biol Cell. 2015;26:91-103 pubmed publisher

product information

Product Type :

Antibody

Product Name :

C16orf62 Polyclonal Antibody

Catalog # :

PA5-28553

Quantity :

100 uL

Price :

US 470.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human

Applications :

Immunohistochemistry (Paraffin): 1:100-1:1,000, Western Blot: 1:500-1:3,000

Species :

Human

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Acts as component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1) (PubMed:28892079). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes (PubMed:28892079). In the endosomes, drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling (PubMed:28892079). Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association with the CCC complex and cooperation with the WASH complex on early endosomes. Seems not to be required for CCC complex stability (PubMed:25355947). [UniProt]

Immunogen :

Recombinant protein fragment corresponding to a region within amino acids 1 and 228 of Human C16orf62

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1:100-1:1,000, Western Blot: 1:500-1:3,000

Aliases :

101F10.2; C16orf62; chromosome 16 open reading frame 62; esophageal cancer associated protein; esophageal cancer-associated protein; UPF0505 protein C16orf62; VPS35 endosomal protein sorting factor-like; VPS35L