Ku70 Polyclonal Antibody | Invitrogen PA5-27538 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Ku70 Polyclonal Antibody

catalog :

PA5-27538

quantity :

100 µL

price :

US 514

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation, immunohistochemistry - paraffin section, proximity ligation assay

more info or order :

Invitrogen product webpage

citations: 4

Published Application/Species/Sample/Dilution	Reference
chromatin immunoprecipitation; human; loading ...; fig 5 immunocytochemistry; human; 1:300; loading ...; fig 8 western blot; human; 1:3000; loading ...; fig 3a	Frost J, Olanubi O, Cheng S, Soriano A, Crisostomo L, Lopez A, et al. The interaction of adenovirus E1A with the mammalian protein Ku70/XRCC6. Virology. 2017;500:11-21 pubmed publisher
	Gui T, Chen Q, Li J, Lu K, Li C, Xu B, et al. Astragaloside IV alleviates 1-deoxysphinganine-induced mitochondrial dysfunction during the progression of chronic kidney disease through p62-Nrf2 antioxidant pathway. Front Pharmacol. 2023;14:1092475 pubmed publisher
	Lee J, Shamanna R, Kulikowicz T, Borhan Fakouri N, Kim E, Christiansen L, et al. CDK2 phosphorylation of Werner protein (WRN) contributes to WRN's DNA double-strand break repair pathway choice. Aging Cell. 2021;20:e13484 pubmed publisher
	Willis N, Panday A, Duffey E, Scully R. Rad51 recruitment and exclusion of non-homologous end joining during homologous recombination at a Tus/Ter mammalian replication fork barrier. PLoS Genet. 2018;14:e1007486 pubmed publisher

image

image 1 :

Immunofluorescence analysis of paraformaldehyde-fixed HeLa cells using Ku70 (XRCC6) (PA5-27538) antibody at 1:200 dilution.

image 2 :

Immunohistochemical analysis of paraffin-embedded D54 xenograft using Ku70 (PA5-27538) antibody at 1:500 dilution.

image 3 :

Western Blot analysis of Ku70 using anti-Ku70 Polyclonal Antibody (PA5-27538), in A431 Cell Lysate (30 ug of cell lysate) and at a dilution of 1:500.

product information

Product Type :

Antibody

Product Name :

Ku70 Polyclonal Antibody

Catalog # :

PA5-27538

Quantity :

100 µL

Price :

US 514

Clonality :

Polyclonal

Purity :

Affinity chromatography

Host :

Rabbit

Reactivity :

Human

Applications :

Immunocytochemistry: 1:100-1:1,000, Immunohistochemistry (Paraffin): 1:100-1:1,000, Immunoprecipitation: 1:500-1:1,000, Proximity Ligation Assay (PLA): Assay-dependent, Western Blot: 1:500-1:3,000

Species :

Human

Isotype :

IgG

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Description :

XRCC6 is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus.

Immunogen :

Recombinant fragment corresponding to a region within amino acids 366 and 607 of Human Ku70

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:100-1:1,000, Immunohistochemistry (Paraffin): 1:100-1:1,000, Immunoprecipitation: 1:500-1:1,000, Proximity Ligation Assay (PLA): Assay-dependent, Western Blot: 1:500-1:3,000

Aliases :

5'-deoxyribose-5-phosphate lyase Ku70; 5'-dRP lyase Ku70; 5'-dRP/AP lyase Ku70; 70 kDa subunit of Ku antigen; 70kDa; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; ATP-dependent DNA helicase II, 70 kDa subunit; CT; CTA-216E10.7; CTC box binding factor 75 kDa subunit; CTC box-binding factor 75 kDa subunit; CTC75; CTCBF; DNA repair protein XRCC6; G22p1; Ku autoantigen p70 subunit; ku autoantigen protein p70 homolog; Ku autoantigen, 70kDa; Ku p70; Ku70; Ku70 DNA-binding component of DNA-dependent proteinkinase complex (thyroid autoantigen 70 kDa); Kup70; Lupus Ku autoantigen protein p70; ML8; OTTHUMP00000028581; thyroid autoantigen; thyroid autoantigen 70 kDa; thyroid autoantigen 70kD (Ku antigen); thyroid autoantigen 70kDa (Ku antigen); Thyroid-lupus autoantigen; thyroid-lupus autoantigen p70; TLAA; XELAEV_18023498mg; X-ray repair complementing defective repair in Chinese hamster cells 6; X-ray repair complementing defective repair in Chinese hamster cells 6 L homeolog; X-ray repair cross complementing 6; X-ray repair cross-complementing protein 6; xrcc6; xrcc6.L

more info or order :

Invitrogen product webpage