LDHB Polyclonal Antibody | Invitrogen PA5-27505 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

LDHB Polyclonal Antibody

catalog :

PA5-27505

quantity :

100 µL

price :

US 485

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, other

more info or order :

Invitrogen product webpage

citations: 6

Published Application/Species/Sample/Dilution	Reference
other; human; 1:100; loading ...; fig 4a	Chen Y, Mahieu N, Huang X, Singh M, Crawford P, Johnson S, et al. Lactate metabolism is associated with mammalian mitochondria. Nat Chem Biol. 2016;12:937-943 pubmed publisher
	HU Z, Yu X, Ding R, Liu B, Gu C, Pan X, et al. Glycolysis drives STING signaling to facilitate dendritic cell antitumor function. J Clin Invest. 2023;133: pubmed publisher
	Park J, Saeed K, Jo M, Kim M, Lee H, Park C, et al. LDHB Deficiency Promotes Mitochondrial Dysfunction Mediated Oxidative Stress and Neurodegeneration in Adult Mouse Brain. Antioxidants (Basel). 2022;11: pubmed publisher
	Martín Bernabé A, Tarragó Celada J, Cunin V, Michelland S, Cortés R, Poignant J, et al. Quantitative Proteomic Approach Reveals Altered Metabolic Pathways in Response to the Inhibition of Lysine Deacetylases in A549 Cells under Normoxia and Hypoxia. Int J Mol Sci. 2021;22: pubmed publisher
	Qing Y, Dong L, Gao L, Li C, Li Y, Han L, et al. R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m6A/PFKP/LDHB axis. Mol Cell. 2021;: pubmed publisher
	Silva L, Poschet G, Nonnenmacher Y, Becker H, Sapcariu S, Gaupel A, et al. Branched-chain ketoacids secreted by glioblastoma cells via MCT1 modulate macrophage phenotype. EMBO Rep. 2017;18:2172-2185 pubmed publisher

image

image 1 :

Immunofluorescence analysis of methanol-fixed HeLa cells using LDH-B (PA5-27505) antibody at 1:50 dilution.

image 2 :

Western Blot analysis using anti-LDH-B Polyclonal Antibody on the following cells: (30 ug of whole cell lysate) A: A549 B: Hela. Primary antibody (PA5-27505) diluted at 1:1000

product information

Product Type :

Antibody

Product Name :

LDHB Polyclonal Antibody

Catalog # :

PA5-27505

Quantity :

100 µL

Price :

US 485

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: 1:100-1:1,000, Immunohistochemistry (Paraffin): 1:100-1:1,000, Western Blot: 1:500-1:3,000

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Description :

This gene encodes an enzyme which catalyzes the reversible conversion of lactate and pyruvate, and NAD and NADH, in the glycolytic pathway. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on the X chromosome and on chromosome. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Immunogen :

Recombinant fragment corresponding to a region within amino acids 118 and 334 of Human LDH-B

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:100-1:1,000, Immunohistochemistry (Paraffin): 1:100-1:1,000, Western Blot: 1:500-1:3,000

Aliases :

AI790582; epididymis secretory protein Li 281; H(B)-type lactate dehydrogenase; HEL-S-281; H-Ldh; lactate dehydrogenase B; lactate dehydrogenase H chain; lactate dehydrogenase-B; lactate dehydrogenase-H; lactate dehydrogenase-H (, EC 1.1.1.27); Lactate dehydrogenease B; LDH heart subunit; Ldh2; Ldh-2; LDHB; LDH-B; LDHBD; LDHH; LDH-H; L-lactate dehydrogenase B chain; Renal carcinoma antigen NY-REN-46; similar to lactate dehydrogenase B; testicular secretory protein Li 25; TRG-5

more info or order :

Invitrogen product webpage