CYP27B1 Polyclonal Antibody | Invitrogen PA5-26065 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CYP27B1 Polyclonal Antibody

catalog :

PA5-26065

quantity :

200 uL

price :

US 464.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, rat

application :

western blot, immunohistochemistry, flow cytometry, immunohistochemistry - paraffin section

citations: 3

Reference
Figueiredo A, Pereira T, Cabrera R, Sim xf5 es Pereira J, Leite V. Malignant Hypercalcemia Due to the Ectopic Production of Calcitriol by an Abdominal Liposarcoma. Cureus. 2023;15:e33446 pubmed publisher
Saito T, Ishida M, Kusabe M, Utsumi T, Maru N, Matsui H, et al. Hypercalcemia Owing to Overproduction of 1,25-Dihydroxyvitamin D3 in Fetal Lung Adenocarcinoma: Case Report. JTO Clin Res Rep. 2021;2:100204 pubmed publisher
Kaukinen A, Pelkonen J, Harvima I. Mast cells express CYP27A1 and CYP27B1 in epithelial skin cancers and psoriasis. Eur J Dermatol. 2015;25:548-55 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CYP27B1 Polyclonal Antibody

Catalog # :

PA5-26065

Quantity :

200 uL

Price :

US 464.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography, Protein A

Host :

Rabbit

Reactivity :

Human, Rat

Applications :

Flow Cytometry: 1:25, Immunohistochemistry (Paraffin): 1:10-1:50, Western Blot: 1:2,000

Species :

Human, Rat

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

CYP27B1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position. This reaction synthesizes 1alpha,25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I.

Immunogen :

KLH conjugated synthetic peptide between 482-508 amino acids from the C-terminal region of human CYP27B1

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1:25, Immunohistochemistry (Paraffin): 1:10-1:50, Western Blot: 1:2,000

Aliases :

1alpha(OH)ase; 25 hydroxyvitamin D3-1-alpha hydroxylase; 25(OH)D 1alpha-hydroxylase; 25-hydroxyvitamin D(3) 1-alpha-hydroxylase; 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial precursor (25-OHD-1 alpha-hydroxylase) (25-hydroxyvitamin D3 1-alpha-hydroxylase) (VD3 1A hydroxylase) (P450C1 alpha) (P450VD1-alpha); 25-hydroxyvitamin D3 1alpha-hydroxylase; 25-OHD-1 alpha-hydroxylase; Calcidiol 1-monooxygenase; Cp2b; cy; Cyp1; CYP1alpha; Cyp27b; Cyp27b1; Cyp40; cytochrome p450 27B1; cytochrome P450 40 (25-hydroxyvitamin D3 1 alpha-hydroxylase); cytochrome P450 family 27 subfamily B member 1; cytochrome P450 subfamily XXVIIB (25-hydroxyvitamin D-1-alpha-hydroxylase) polypeptide 1; cytochrome P450 subfamily XXVIIB polypeptide 1; cytochrome P450, 27b1; cytochrome P450, 40 (25-hydroxyvitamin D3 1 alpha-hydroxylase); cytochrome P450, family 27, subfamily B, polypeptide 1; cytochrome P450, subfamily 27b, polypeptide 1; cytochrome P450C1 alpha; Cytochrome P450VD1-alpha; P450c1; P450C1 alpha; P450VD1alpha; P450VD1-alpha; Pddr; VD3 1A hydroxylase; Vdd1; Vddr; VDDRI; VDR