KIR2DL2 Polyclonal Antibody | Invitrogen PA5-25666 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

KIR2DL2 Polyclonal Antibody

catalog :

PA5-25666

quantity :

400 uL

price :

US 464.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, flow cytometry

product information

Product Type :

Antibody

Product Name :

KIR2DL2 Polyclonal Antibody

Catalog # :

PA5-25666

Quantity :

400 uL

Price :

US 464.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography, Protein A

Host :

Rabbit

Reactivity :

Human

Applications :

Flow Cytometry: 1:10-1:50, Western Blot: 1:1,000

Species :

Human

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.

Immunogen :

KLH conjugated synthetic peptide between 263-291 amino acids from the C-terminal region of human KIR2DL2

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1:10-1:50, Western Blot: 1:1,000

Aliases :

CD158 antigen-like family member B1; CD158b; CD158B1; killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 2; killer cell immunoglobulin-like receptor 2DL2; killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2; KIR2DL2; MHC class I NK cell receptor; natural killer cell receptor; natural killer-associated transcript 6; NKAT6; NKAT-6; p58 natural killer cell receptor clone CL-43; p58 NK receptor CL-43; p58.2