TMEM66 Polyclonal Antibody | Invitrogen PA5-24237 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TMEM66 Polyclonal Antibody

catalog :

PA5-24237

quantity :

400 uL

price :

US 474.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, flow cytometry

more info or order :

Invitrogen product webpage

citations: 7

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; loading ...; fig 1a	Albarrán L, Regodón S, Salido G, Lopez J, Rosado J. Role of STIM1 in the surface expression of SARAF. Channels (Austin). 2017;11:84-88 pubmed publisher
	Jardin I, Nieto Felipe J, Alvarado S, Diez Bello R, Lopez J, Salido G, et al. SARAF and EFHB Modulate Store-Operated Ca2+ Entry and Are Required for Cell Proliferation, Migration and Viability in Breast Cancer Cells. Cancers (Basel). 2021;13: pubmed publisher
	Galeano Otero I, del Toro R, Khatib A, Rosado J, Ordóñez Fernández A, Smani T. SARAF and Orai1 Contribute to Endothelial Cell Activation and Angiogenesis. Front Cell Dev Biol. 2021;9:639952 pubmed publisher
	Sanlialp A, Schumacher D, Kiper L, Varma E, Riechert E, Ho T, et al. Saraf-dependent activation of mTORC1 regulates cardiac growth. J Mol Cell Cardiol. 2020;141:30-42 pubmed publisher
	Lopez E, Frischauf I, Jardin I, Derler I, Muik M, Cantonero C, et al. STIM1 phosphorylation at Y316 modulates its interaction with SARAF and the activation of SOCE and I CRAC. J Cell Sci. 2019;132: pubmed publisher
	Albarrán L, Lopez J, Jardin I, Sanchez Collado J, Berna Erro A, Smani T, et al. EFHB is a Novel Cytosolic Ca2+ Sensor That Modulates STIM1-SARAF Interaction. Cell Physiol Biochem. 2018;51:1164-1178 pubmed publisher
	Albarrán L, Lopez J, Amor N, Martin Cano F, Berna Erro A, Smani T, et al. Dynamic interaction of SARAF with STIM1 and Orai1 to modulate store-operated calcium entry. Sci Rep. 2016;6:24452 pubmed publisher

product information

Product Type :

Antibody

Product Name :

TMEM66 Polyclonal Antibody

Catalog # :

PA5-24237

Quantity :

400 uL

Price :

US 474.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography, Protein A

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Flow Cytometry: 1:10-1:50, Western Blot: 1:1,000

Species :

Human, Mouse

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Saraf encodes a protein that is a negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the de-oligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions.

Immunogen :

KLH conjugated synthetic peptide between 33-62 amino acids from the N-terminal region of human TMEM66

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1:10-1:50, Western Blot: 1:1,000

Aliases :

1810045K07Rik; arrestin-E; FOAP-7; HBV XAg-transactivated protein 3; HBV X-transactivated gene 3 protein; HSPC035; NPD003; Protein FOAP-7; PSEC0019; Saraf; SARAF long isoform; SARAF short isoform; SOCE-associated regulatory factor; store-operated calcium entry associated regulatory factor; store-operated calcium entry-associated regulatory factor; testicular secretory protein Li 59; TMEM66; Transmembrane protein 66; UNQ1967/PRO4499; XTP3

more info or order :

Invitrogen product webpage