HTRA1 Polyclonal Antibody | Invitrogen PA5-23395 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

HTRA1 Polyclonal Antibody

catalog :

PA5-23395

quantity :

100 uL

price :

US 464.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dogs, bovine

application :

western blot, immunocytochemistry

product information

Product Type :

Antibody

Product Name :

HTRA1 Polyclonal Antibody

Catalog # :

PA5-23395

Quantity :

100 uL

Price :

US 464.00

Clonality :

Polyclonal

Host :

Rabbit

Reactivity :

Bovine, Canine, Human, Mouse, Non-human primate, Rat

Applications :

Immunocytochemistry: 1:10-1:2,000, Western Blot: 1:250-1:1,000

Species :

Bovine, Canine, Human, Mouse, Non-human primate, Rat

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

HtrA1, a 51KDa protein, is a member of highly conserved mammalian HtrA serine protease family. It is a human homolog of bacterial HtrA and consists of a secretory signal sequence, an IGFBP-binding domain and a Kazal-type serine-protease inhibitor domain at the N-terminus and a highly conserved trypsin-like serine/protease domain and a PDZ domain at the C-terminus. It plays a major role in the regulation of cell growth. HtrA1 inhibits signaling mediated by TGF-beta family members and regulates many physiological processes. HtrA1 is up-regulated in placenta during pregnancy and plays an important role in implantation and placental physiology. It regulates the availability of IGFs by cleaving IGF-binding proteins. It acts as a tumor suppressor and is down-regulated in ovarian cancers and melanomas. Its role has been implicated in osteoarthritis suggesting a therapeutic intervention. Northern blot analysis detected high expression in placenta.

Immunogen :

Within the range of amino acids 234-262 of human HtrA1

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:10-1:2,000, Western Blot: 1:250-1:1,000

Aliases :

AI429470; ARMD7; CADASIL2; CARASIL; High-temperature requirement A serine peptidase 1; HTRA; HtrA serine peptidase 1; Htra1; IGF binding; IGFBP5-protease; insulin-like growth factor binding protein 5 protease; L56; ORF480; protease serine 11; protease, serine, 11; protease, serine, 11 (IGF binding); PRSS11; RSPP11; serine protease; serine protease 11; Serine protease HTRA1; similar to bacterial htrA and degP