HDAC9 Polyclonal Antibody | Invitrogen PA5-23346 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

HDAC9 Polyclonal Antibody

catalog :

PA5-23346

quantity :

100 ug

price :

US 470.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, dogs, bovine

application :

western blot

citations: 1

Reference
Blixt N, Faulkner B, Astleford K, Lelich R, Schering J, Spencer E, et al. Class II and IV HDACs function as inhibitors of osteoclast differentiation. PLoS ONE. 2017;12:e0185441 pubmed publisher

product information

Product Type :

Antibody

Product Name :

HDAC9 Polyclonal Antibody

Catalog # :

PA5-23346

Quantity :

100 ug

Price :

US 470.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Bovine, Canine, Human, Mouse, Non-human primate

Applications :

Western Blot: 0.5-2 ug/mL

Species :

Bovine, Canine, Human, Mouse, Non-human primate

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is a critical component of transcriptional regulation and the acetylation of nucleosomal histones is a major source of this remodeling. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Several mammalian proteins function as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1 and the TFIID subunit TAF II p250. Conversely, the deacetylation of histones is associated with transcriptional silencing. The histone deacetylases (HDAC) include HDAC1-9. HDAC9 and HDAC9a are two alternatively spliced isoforms of HDAC9. HDAC9a is 132 amino acids shorter than HDAC9, but both isoforms contain the HDAC catalytic domain, remain capable of deacetylase activity and repress myoctye enhancer-binding factor 2-mediated transcription. HDAC9 and HDAC9a are expressed in brain, skeletal muscle, kidney, placenta and pancreas.

Immunogen :

A portion of amino acids 100-150 of human HDAC-9

Format :

Liquid

Applications w/Dilutions :

Western Blot: 0.5-2 ug/mL

Aliases :

AV022454; D030072B18Rik; DKFZp779K1053; HD7; HD7b; HD9; HDAC; HDAC7; Hdac7b; HDAC9; hdac-9; HDAC9B; HDAC9FL; HDRP; histone deacetylase 4/5-related protein; histone deacetylase 7B; Histone deacetylase 9; histone deacetylase-related protein; KIAA0744; MEF-2 interacting transcription repressor (MITR) protein; MEF2-interacting transcription repressor MITR; Mitr; mKIAA0744; RGD1310748; RGD1563092; TWIST