beta Arrestin 1 Polyclonal Antibody | Invitrogen PA5-23342 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

beta Arrestin 1 Polyclonal Antibody

catalog :

PA5-23342

quantity :

100 µg

price :

375 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, bovine, zebrafish

application :

western blot

product information

Product Type :

Antibody

Product Name :

beta Arrestin 1 Polyclonal Antibody

Catalog # :

PA5-23342

Quantity :

100 µg

Price :

375 USD

Clonality :

Polyclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Bovine, Human, Mouse, Rat, Zebrafish

Applications :

Western Blot: 2.0-3 µg/mL

Species :

Bovine, Human, Mouse, Rat, Zebrafish

Isotype :

IgG

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Description :

Beta Arrestin 1 is a member of a family of proteins widely expressed but especially abundant in the central nervous system. Serving as an adaptor or scaffold molecule, beta Arrestin 1 is essential for mitogenic signaling and mediates agonist-dependent desensitization and internalization of Gprotein-coupled receptors (GPCRs, e.g., beta 2-adrenergic receptor). After binding to their ligand and interacting with heterotrimeric G proteins, GPCRs are phosphorylated by G-protein receptor kinases (GRKs) on serine residues. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane. Serine 412 is then dephosphorylated and the GPCRs are internalized, leading to activation of the Ras, Raf, ERK1 and 2 signaling pathway.

Immunogen :

Synthetic peptide (334 LLGDLASSDVAVELPFT 350) of Beta-arrestin 1 protein.

Format :

Liquid

Applications w/Dilutions :

Western Blot: 2.0-3 µg/mL

Aliases :

1200006I17Rik; ARB1; ARR1; ARRB1; ARRB1 protein; arrdc1; arrestin; arrestin 2; arrestin beta 1; arrestin beta-1; arrestin, beta 1; arrestin-2; AW208571; BARRES; beta-arrestin; beta-arrestin1; beta-arrestin-1; G430100A01Rik; Non-visual arrestin-2