beta-Arrestin 2 Polyclonal Antibody | Invitrogen PA5-23296 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

beta-Arrestin 2 Polyclonal Antibody

catalog :

PA5-23296

quantity :

100 ug

price :

US 464.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dogs, bovine, zebrafish , domestic horse

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

product information

Product Type :

Antibody

Product Name :

beta-Arrestin 2 Polyclonal Antibody

Catalog # :

PA5-23296

Quantity :

100 ug

Price :

US 464.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Bovine, Canine, Chicken, Equine, Human, Mouse, Non-human primate, Rat, Xenopus laevis, Zebrafish

Applications :

Immunohistochemistry (Paraffin): 5 ug/mL, Western Blot: 0.25-0.5 ug/mL

Species :

Bovine, Canine, Chicken, Equine, Human, Mouse, Non-human primate, Rat, Xenopus laevis, Zebrafish

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Beta-arrestin-2, or ARRB2, is an adaptor protein belonging to the arrestin family with an N- arrestin domain and a C- arrestin domain. ARRB2 is a regulatory protein involved in heterotrimeric G protein-coupled receptor desensitization and is known to regulate beta2-adrenergic receptor (beta2AR) function by enhancing beta2AR mediated nuclear translocation of ERK. ARRB2 binds to phosphorylated beta2ARs, thereby causing a significant impairment of their capacity to activate G(S) proteins. Along with AIP4, ARRB2 acts as an endosomal sorting molecule that mediates CXCR4 entry into a degradative pathway. It may also be involved in hormone-specific desensitization of TSH receptors. ARRB2 is a Ca2+ binding protein of the retinal outer segments and binds to P-rhodopsin and is also involved in synaptic transmission in photoreceptor cells. It is widely expressed in most of the tissues, especially neuronal tissues and spleen.

Immunogen :

A peptide sequence corresponding to an area between amino acids 1 and 50 of human ARRB2

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 5 ug/mL, Western Blot: 0.25-0.5 ug/mL

Aliases :

AI326910; ARB2; ARR2; ARRB2; arrestin 3; arrestin beta 2; arrestin beta-2; arrestin, beta 2; arrestin-3; AW122872; BARR2; BARRES; beta arr2; beta-arrestin 2 long isoform; beta-arrestin 2 short isoform; beta-arrestin-2; Non-visual arrestin-3