DAAM1 Polyclonal Antibody | Invitrogen PA5-23222 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

DAAM1 Polyclonal Antibody

catalog :

PA5-23222

quantity :

100 µg

price :

375 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dogs, bovine, domestic horse

application :

western blot

product information

Product Type :

Antibody

Product Name :

DAAM1 Polyclonal Antibody

Catalog # :

PA5-23222

Quantity :

100 µg

Price :

375 USD

Clonality :

Polyclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Bovine, Canine, Equine, Human, Mouse, Rat

Applications :

Western Blot: 4.0-6 µg/mL

Species :

Bovine, Canine, Equine, Human, Mouse, Rat

Isotype :

IgG

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Description :

DAAM1 is a diaphanous-related formin first studied as a novel Disheveled binding protein and shown to be crucial for the planar cell polarity pathway in Xenopus. DAAM1, like other formins, directs nucleation and elongation of new actin filaments using its conserved formin-homology-2 (FH2) domain. It is a Rho-regulated formin implicated in neuronal development and regulation of gastrulation. It was identified as a binding protein of the Wnt receptor-associated protein Disheveled. It also binds the GTP-bound RhoA and increases its GTP-bound form population in cells. It exists in an autoinhibited state via intramolecular interactions between its amino-terminal GBD and carboxyl-terminal DAD domains. Structurally the protein includes a GTPase-binding domain (GBD), a diaphanous inhibitory domain (DID), and a coiled-coil region followed by the FH1, FH2 and C-terminal diaphanous auto-regulatory domain (DAD). In humans, the DAAM1 gene is mapped to chromosome 14q23.1.

Immunogen :

Synthetic peptide (18 FRNNDHPEITYRLRNDSN 35) of DAAM1 protein.

Format :

Liquid

Applications w/Dilutions :

Western Blot: 4.0-6 µg/mL

Aliases :

DAAM1; Disheveled-associated activator of morphogenesis 1; dishevelled associated activator of morphogenesis 1; KIAA0666