AMBRA1 Polyclonal Antibody | Invitrogen PA5-23212 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

AMBRA1 Polyclonal Antibody

catalog :

PA5-23212

quantity :

100 ug

price :

US 454.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, chicken, bovine

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

product information

Product Type :

Antibody

Product Name :

AMBRA1 Polyclonal Antibody

Catalog # :

PA5-23212

Quantity :

100 ug

Price :

US 454.00

Clonality :

Polyclonal

Purity :

Protein G

Host :

Rabbit

Reactivity :

Bovine, Chicken, Human, Mouse, Rat

Applications :

Immunohistochemistry (Paraffin): 10 ug/mL, Western Blot: 0.5-2 ug/mL

Species :

Bovine, Chicken, Human, Mouse, Rat

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. Beclin-1, a principal regulator of autophagosome formation, is in turn regulated by Ambra1. Ambra1 associates with Beclin-1 through a region near its center as determined by yeast two-hybrid assay. Null mutations in this gene in mice resulted in embryonic lethality with severe neural tube defects associated with autophagy impairment, accumulation of ubiquitinated proteins, unbalanced cell proliferation and excessive apoptotic death. Furthermore, down-regulation of Ambra1 in cultured cells though RNA interference decreased the level of rapamycin- and nutrient starvation-induced autophagy. Multiple isoforms of Ambra1 are known to exist.

Immunogen :

A portion of amino acids 1-50 of human Ambra1

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 10 ug/mL, Western Blot: 0.5-2 ug/mL

Aliases :

2310079H06Rik; A130023A14; AA474864; activating molecule in beclin-1-regulated autophagy; activating molecule in Beclin1-regulated autophagy; activating molecule in BECN1-regulated autophagy protein 1; AMBRA1; autophagy and beclin 1 regulator 1; autophagy/beclin 1 regulator 1; autophagy/beclin-1 regulator 1; AV021921; D030051N19Rik; DCAF3; DDB1 and CUL4 associated factor 3; hypothetical protein; hypothetical protein LOC517263; ischemia related factor NYW-1; Kiaa1736; mKIAA1736; Nyw1; WD repeat domain 94; WDR94