MTSS1 Polyclonal Antibody | Invitrogen PA5-23200 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

MTSS1 Polyclonal Antibody

catalog :

PA5-23200

quantity :

100 µg

price :

US 375.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dogs, chicken

application :

western blot

product information

Product Type :

Antibody

Product Name :

MTSS1 Polyclonal Antibody

Catalog # :

PA5-23200

Quantity :

100 µg

Price :

US 375.00

Clonality :

Polyclonal

Purity :

Protein G

Host :

Rabbit

Reactivity :

Canine, Chicken, Human, Mouse, Non-human primate, Rat

Applications :

Western Blot: 2-4 µg/mL

Species :

Canine, Chicken, Human, Mouse, Non-human primate, Rat

Isotype :

IgG

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Description :

Metastasis suppressor protein 1 (MTSS1) [MIM, "missing in metastasis"], was first discovered as missing transcripts from metastatic bladder and prostate cancer cells. MTSS1 is a 755 amino acid protein, having multidomain and scaffolding function. It has a proline-rich/SH3 binding region and a serine-rich region with EGF or PDGF/Src consensus sites. It contains anactin-binding Wiskott-Aldrich syndrome protein homology-2 motif (WH2) at the C-terminus while the N-terminal IMD domain (IRSp53-MIM domain) interact with membranes and bundle actin filament. The WH2 domain binds to actin monomers and plays an important role in actin cytoskeleton reorganization. Recently, MIM was found to interact with cortactin via SH3 domains. In addition, MTSS1 enhanced cortactin- and Arp2/3-dependent actin polymerization. It is thus involved in cell motility and morphogenesis and also interacts with sonic hedgehog/Gli signaling in epidermal cells. MTSS1 acts as an important regulator of cell growth and development and is known to express in many tissues, including spleen, thymus, prostate, testis, uterus, colon, and peripheral blood.

Immunogen :

Synthetic peptide (176 LEETEKQAVRKALIEERGRFC 196) of MTSS1 protein.

Format :

Liquid

Applications w/Dilutions :

Western Blot: 2-4 µg/mL

Aliases :

2310003N14Rik; actin monomer-binding protein; BC024131; D130001D01Rik; hypothetical protein; KIAA0429; metastasis suppressor 1; metastasis suppressor protein 1; Metastasis suppressor YGL-1; Mim; MIMA; MIMB; missing in metastasis protein; mKIAA0429; MTSS I-BAR domain containing 1; MTSS1; MTSS1, I-BAR domain containing; Protein MTSS 1; protein MTSS 1; metastasis suppressor protein 1