This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
RNF128 Polyclonal Antibody
catalog :
PA5-23164
quantity :
100 ug
price :
US 474.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat, dogs, domestic horse
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section
product information
Product Type :
Antibody
Product Name :
RNF128 Polyclonal Antibody
Catalog # :
PA5-23164
Quantity :
100 ug
Price :
US 474.00
Clonality :
Polyclonal
Purity :
protein A
Host :
Rabbit
Reactivity :
Canine, Equine, Human, Mouse, Non-human primate, Rat
Applications :
Immunocytochemistry: Assay-Dependent, Immunohistochemistry (Paraffin): 5-10 ug/mL, Western Blot: 0.5-2 ug/mL
Species :
Canine, Equine, Human, Mouse, Non-human primate, Rat
Isotype :
IgG
Storage :
Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.
Description :
GRAIL is a type I transmembrane protein that localizes to the endocytic pathway and contains a PA (protease associated) domain and a RING-type zinc finger domain. It is a ubiquitin-protein isopeptide ligase (E3) necessary for the induction of CD4(+) T cell anergy in vivo and induced expression of this protein was observed in anergic CD4 (+) T cells, which suggested a role in the induction of anergic phenotype. It is differentially expressed in naturally occurring and peripherally induced CD25 (+) T regulatory cells and the expression is linked to the conversion of these cells to a regulatory phenotype. Expression of GRAIL in retrovirally transduced T cell hybridomas limits activation-induced IL-2 and IL-4 cytokine production. It also functions in the patterning of the dorsal ectoderm and sensitizes ectoderm to respond to neural-inducing signals.
Immunogen :
A synthetic peptide corresponding to amino acids  portion of amino acids 227-269 of human GRAIL
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: Assay-Dependent, Immunohistochemistry (Paraffin): 5-10 ug/mL, Western Blot: 0.5-2 ug/mL
Aliases :
1300002C13Rik; AI987883; E3 ubiquitin-protein ligase RNF128; Gene related to anergy in lymphocytes protein; goliath-related E3 ubiquitin-protein ligase 1; Grail; Greul1; MNCb-3816; RGD1566282; RING finger protein 128; ring finger protein 128, E3 ubiquitin protein ligase; RING-type E3 ubiquitin transferase RNF128; RNF128; RP11-150F24.1
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA