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antibody

KV1.2 (KCNA2) Polyclonal Antibody

PA5-23005

100 µL

US 402.00

polyclonal

domestic rabbit

nonconjugated

human, mouse, rat, dogs, bovine, pigs , zebrafish , Xenopus laevis

western blot, immunoprecipitation

KV1.2 (KCNA2) Polyclonal Antibody

PA5-23005

100 µL

US 402.00

Polyclonal

Antigen affinity chromatography

Rabbit

Bovine, Canine, Human, Mouse, Porcine, Rat, Xenopus laevis, Zebrafish

Immunoprecipitation: 1:10-1:500, Western Blot: 1:500-1:1,000

Bovine, Canine, Human, Mouse, Porcine, Rat, Xenopus laevis, Zebrafish

IgG

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Kcna2 is a voltage-gated potassium channel (KV) that belongs to the 6-TM family of potassium channel and also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers. Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. The diverse functions of potassium channels include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). The Kcna2 gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. Kcna2 contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. Further, Kcna2 belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of the Kcna2 gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1. Diseases associated with KCNA2 include Epileptic Encephalopathy (Early Infantile, 32) and Undetermined Early-Onset Epileptic Encephalopathy.

Synthetic peptide made to rat Kv1.2 (within residues 50-100), which is identical in all members of the Kv1 family.

Liquid

Immunoprecipitation: 1:10-1:500, Western Blot: 1:500-1:1,000

Akr6a4; BK2; CSMK1; delayed rectifier K+ channel; EIEE32; ENSMUSG00000074335; Gm10672; HBK5; HK4; HUKIV; k(v)1.2; KC22; Kca1-2; kcna2; kcna2.S; kcna2-a; KV1.2; Kv1.2' potassium channel; LOC100537815; MK2; Mk-2; NGK1; Potassium (K+) channel protein alpha 2, voltage dependent; potassium channel (BGK5); potassium channel subunit Kv 1.2; potassium channel, voltage gated shaker related subfamily A, member 2; potassium channel, voltage gated shaker related subfamily A, member 2 S homeolog; potassium voltage gated channel shaker related subfamily member 2; potassium voltage-gated channel subfamily A member 2; potassium voltage-gated channel, shaker-related subfamily, member 2; potassium voltage-gated channel, shaker-related subfamily, member 2 a; RAK; RBK2; RCK5; RP11-284N8.1; voltage-dependent K channel; voltage-gated channel, shaker-related subfamily, member 2; voltage-gated K(+) channel HuKIV; Voltage-gated potassium channel HBK5; voltage-gated potassium channel isoform 2; voltage-gated potassium channel isoform 3; voltage-gated potassium channel protein Kv1.2; Voltage-gated potassium channel subunit Kv1.2; XELAEV_18011981mg; XSha2