LDLR Polyclonal Antibody | Invitrogen PA5-22976 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

LDLR Polyclonal Antibody

catalog :

PA5-22976

quantity :

100 uL

price :

US 470.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

citations: 6

Reference
Buldak L, Machnik G, Skudrzyk E, Boldys A, Maliglowka M, Kosowski M, et al. Exenatide prevents statin-related LDL receptor increase and improves insulin secretion in pancreatic beta cells (1.1E7) in a protein kinase A-dependent manner. J Appl Biomed. 2022;20:130-140 pubmed publisher
Sreekumar P, Su F, Spee C, Araujo E, Nusinowitz S, Reddy S, et al. Oxidative Stress and Lipid Accumulation Augments Cell Death in LDLR-Deficient RPE Cells and Ldlr-/- Mice. Cells. 2022;12: pubmed publisher
Taiarol L, Bigogno C, Sesana S, Kravicz M, Viale F, Pozzi E, et al. Givinostat-Liposomes: Anti-Tumor Effect on 2D and 3D Glioblastoma Models and Pharmacokinetics. Cancers (Basel). 2022;14: pubmed publisher
Feldt M, Menard J, Rosendahl A, Lettiero B, Bendahl P, Belting M, et al. The effect of statin treatment on intratumoral cholesterol levels and LDL receptor expression: a window-of-opportunity breast cancer trial. Cancer Metab. 2020;8:25 pubmed publisher
André S, Larbanoix L, Verteneuil S, Stanicki D, Nonclercq D, Vander Elst L, et al. Development of an LDL Receptor-Targeted Peptide Susceptible to Facilitate the Brain Access of Diagnostic or Therapeutic Agents. Biology (Basel). 2020;9: pubmed publisher
Maras J, Das S, Bhat A, Kumar Vyas A, Yadav G, Chaudhary S, et al. Dysregulated Lipid Transport Proteins Correlate With Pathogenesis and Outcome in Severe Alcoholic Hepatitis. Hepatol Commun. 2019;3:1598-1625 pubmed publisher

product information

Product Type :

Antibody

Product Name :

LDLR Polyclonal Antibody

Catalog # :

PA5-22976

Quantity :

100 uL

Price :

US 470.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Immunocytochemistry: 1-2 ug/mL, Immunohistochemistry (Paraffin): 1:200-1:1,000, Western Blot: 0.5-2 ug/mL

Species :

Human, Mouse

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

The low density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in the LDL-R gene cause the autosomal dominant disorder, familial hypercholesterolemia. Along with SCARB1, CLDN1, and the tetraspanin superfamily member CD81, LDL-R has been reported to be an entry factor for the Hepatitis C virus. At least three isoforms of LDL-R are known to exist.

Immunogen :

Synthetic peptide made to an internal portion of the human protein (within residues 500-550).

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1-2 ug/mL, Immunohistochemistry (Paraffin): 1:200-1:1,000, Western Blot: 0.5-2 ug/mL

Aliases :

FH; FHC; Hlb301; I79_005860; LDL receptor; LDLA; LDLCQ2; LDLR; ldl-r; LDLRA; low density lipoprotein receptor; low density lipoprotein receptor protein; low-density lipoprotein receptor; low-density lipoprotein receptor class A domain-containing protein 3