LC3B Polyclonal Antibody, Biotin | Invitrogen PA5-22709 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

LC3B Polyclonal Antibody, Biotin

catalog :

PA5-22709

quantity :

100µL

price :

330 USD

clonality :

polyclonal

host :

rabbit

conjugate :

biotin

reactivity :

Chinese hamster, human, mouse, rat, dog, cow, pig, zebrafish

application :

western blot, immunohistochemistry, immunoprecipitation, immunohistochemistry - paraffin section

product information

Product Type :

Antibody

Product Name :

LC3B Polyclonal Antibody, Biotin

Catalog # :

PA5-22709

Quantity :

100µL

Price :

330 USD

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Bacteria, Bovine, Canine, Hamster, Human, Mouse, Non-human primate, Porcine, Rat, Zebrafish

Applications :

Immunohistochemistry (Paraffin): 1:200-1:400, Immunoprecipitation: 20 µg/500 µg of protein, Western Blot: 2 µg/mL

Species :

Bacteria, Bovine, Canine, Hamster, Human, Mouse, Non-human primate, Porcine, Rat, Zebrafish

Isotype :

IgG

Storage :

4° C, store in dark

Description :

LC3B (Autophagy Marker Light Chain 3B, MAP1A/MAP1B LC3 B) in humans, is encoded by the gene MAP1LC3B (Microtubule-associated proteins 1A/1B light chain 3B). LC3B is associated with microtubule assembly and important is in neurogenesis. Recent studies indicate that LC3B plays a vital role in autophagy, a process that involves the bulk degradation of cytoplasmic component. Three human LC3 isoforms undergo post-translational modifications during autophagy. Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). LC3B is a microtubule-associated protein that mediate the physical interactions between microtubules and components of the cytoskeleton. LC3B may play a role in processes involving cancer, aging, metabolic and neurodegenerative disorders and cardiovascular/pulmonary diseases.

Immunogen :

A synthetic peptide made to an N-terminal portion of the human LC3 protein sequence (between residues 1-100).

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1:200-1:400, Immunoprecipitation: 20 µg/500 µg of protein, Western Blot: 2 µg/mL

Aliases :

RP11-346K17.1, ATG8E, LC3, LC3A, MAP1ALC3, MAP1BLC3, MAP1 light chain 3-like protein 1, MAP1A/1B light chain 3 A, MAP1A/MAP1B LC3 A, MAP1A/MAP1B light chain 3 A, autophagy-related protein LC3 A, autophagy-related ubiquitin-like modifier LC3 A, microtubule-associated proteins 1A/1B light chain 3, microtubule-associated proteins 1A/1B light chain 3A