ASL Polyclonal Antibody | Invitrogen PA5-22300 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

ASL Polyclonal Antibody

catalog :

PA5-22300

quantity :

100 uL

price :

US 470.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

citations: 5

Reference
Miljkovic M, Seguin A, Jia X, Cox J, Catrow J, Bergonia H, et al. Loss of the mitochondrial protein Abcb10 results in altered arginine metabolism in MEL and K562 cells and nutrient stress signaling through ATF4. J Biol Chem. 2023;299:104877 pubmed publisher
Cabanes Creus M, Navarro R, Liao S, Scott S, Carlessi R, Roca Pinilla R, et al. Characterization of the humanized FRG mouse model and development of an AAV-LK03 variant with improved liver lobular biodistribution. Mol Ther Methods Clin Dev. 2023;28:220-237 pubmed publisher
Missiaen R, Anderson N, Kim L, Nance B, Burrows M, Skuli N, et al. GCN2 inhibition sensitizes arginine-deprived hepatocellular carcinoma cells to senolytic treatment. Cell Metab. 2022;34:1151-1167.e7 pubmed publisher
Lange S, McKell M, Schmidt S, Hossfeld A, Chaturvedi V, Kinder J, et al. l-Citrulline Metabolism in Mice Augments CD4+ T Cell Proliferation and Cytokine Production In Vitro, and Accumulation in the Mycobacteria-Infected Lung. Front Immunol. 2017;8:1561 pubmed publisher
Rapovy S, Zhao J, Bricker R, Schmidt S, Setchell K, Qualls J. Differential Requirements for L-Citrulline and L-Arginine during Antimycobacterial Macrophage Activity. J Immunol. 2015;195:3293-300 pubmed publisher

product information

Product Type :

Antibody

Product Name :

ASL Polyclonal Antibody

Catalog # :

PA5-22300

Quantity :

100 uL

Price :

US 470.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Immunocytochemistry: 1:100-1:1,000, Immunohistochemistry (Paraffin): 1:100-1:1,000, Western Blot: 1:500-1:3,000

Species :

Human, Mouse

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

ASL encodes a member of the lyase 1 family. The encoded protein forms a cytosolic homotetramer and primarily catalyzes the reversible hydrolytic cleavage of argininosuccinate into arginine and fumarate, an essential step in the liver in detoxifying ammonia via the urea cycle. Mutations in this gene result in the autosomal recessive disorder argininosuccinic aciduria, or argininosuccinic acid lyase deficiency. A nontranscribed pseudogene is also located on the long arm of chromosome 22. Alternatively spliced transcript variants encoding different isoforms have been described.

Immunogen :

Recombinant protein fragment contain a sequence corresponding to a region within amino acids 13 and 261 (P04424) of ASL

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:100-1:1,000, Immunohistochemistry (Paraffin): 1:100-1:1,000, Western Blot: 1:500-1:3,000

Aliases :

2510006M18Rik; argininosuccinase; argininosuccinate lyase; Arginosuccinase; ASAL; Asl