GAD65 Polyclonal Antibody | Invitrogen PA5-22260 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

GAD65 Polyclonal Antibody

catalog :

PA5-22260

quantity :

100 uL

price :

US 514.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

citations: 9

Reference
Gorai P, Rastogi S, Bharti P, Agarwal S, Pal S, Sharma M, et al. Deciphering pancreatic neuroendocrine tumors: Unveiling through circulating small extracellular vesicles. Heliyon. 2024;10:e29079 pubmed publisher
Bhave S, Guyer R, Picard N, Omer M, Hotta R, Goldstein A. Ednrb -/- mice with hirschsprung disease are missing Gad2-expressing enteric neurons in the ganglionated small intestine. Front Cell Dev Biol. 2022;10:917243 pubmed publisher
Huang R, Worrell J, Garner E, Wang S, Homsey T, Xu B, et al. Epidural electrical stimulation of the cervical spinal cord opposes opioid-induced respiratory depression. J Physiol. 2022;600:2973-2999 pubmed publisher
Christoffel D, Walsh J, Heifets B, Hoerbelt P, Neuner S, Sun G, et al. Input-specific modulation of murine nucleus accumbens differentially regulates hedonic feeding. Nat Commun. 2021;12:2135 pubmed publisher
Zanni G, Goto S, Fragopoulou A, Gaudenzi G, Naidoo V, Di Martino E, et al. Lithium treatment reverses irradiation-induced changes in rodent neural progenitors and rescues cognition. Mol Psychiatry. 2021;26:322-340 pubmed publisher
Sun Z, Meng F, Tu L, Sun L. Myricetin attenuates the severity of seizures and neuroapoptosis in pentylenetetrazole kindled mice by regulating the of BDNF-TrkB signaling pathway and modulating matrix metalloproteinase-9 and GABAA. Exp Ther Med. 2019;17:3083-3091 pubmed publisher
Kim J, Kim Y, Lee H, Jin H, Neupane C, Kim S, et al. GABAergic signaling linked to autophagy enhances host protection against intracellular bacterial infections. Nat Commun. 2018;9:4184 pubmed publisher
Cherif K, Gerard C, Rousseau J, Ouellet D, Chapdelaine P, Tremblay J. Increased Frataxin Expression Induced in Friedreich Ataxia Cells by Platinum TALE-VP64s or Platinum TALE-SunTag. Mol Ther Nucleic Acids. 2018;12:19-32 pubmed publisher
Martínez J, Rahsepar B, White J. Anatomical and Electrophysiological Clustering of Superficial Medial Entorhinal Cortex Interneurons. Eneuro. 2017;4: pubmed publisher

product information

Product Type :

Antibody

Product Name :

GAD65 Polyclonal Antibody

Catalog # :

PA5-22260

Quantity :

100 uL

Price :

US 514.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: 1:100-1:1,000, Immunohistochemistry (Paraffin): 1:100-1:1,000, Western Blot: 1:500-1:3,000

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

GAD65 (glutamic acid decarboxylase-65) are present in autoimmune disorders such as insulin-dependent (type1) diabetes mellitus (IDDM), stiff man syndrome and polyendocrine autoimmune disease. Auto-antibodies to GAD65 are present in 60-70% of individuals with newly diagnosed IDDM and thus are important markers for disease activity. These auto-antibodies usually recognize conformation-dependent regions on GAD65 and rarely bind to the second isoform, GAD67. Auto-antibodies to GAD67 are found in only 15% of recent-onset IDDM patients and most of this binding can be blocked with GAD65, suggesting shared epitopes between the two isoforms of GAD.

Immunogen :

Recombinant fragment corresponding to a region within amino acids 353 and 585 of GAD65 (Uniprot ID#Q05329)

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:100-1:1,000, Immunohistochemistry (Paraffin): 1:100-1:1,000, Western Blot: 1:500-1:3,000

Aliases :

6330404F12Rik; 65 kDa glutamic acid decarboxylase; GAD(65); GAD2; Gad-2; GAD65; GAD-65; Glutamate decarboxylase 2; Glutamate decarboxylase 2 (islet); glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); glutamate decarboxylase 65 kDa isoform; Glutamate decarboxylase-2 (pancreas); glutamic acid decarboxylase 2; glutamic acid decarboxylase 65; MGC161605; MGC161607; RP11-420F12.2