IFIT3 Polyclonal Antibody | Invitrogen PA5-22230 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IFIT3 Polyclonal Antibody

catalog :

PA5-22230

quantity :

100 uL

price :

US 470.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

citations: 5

Reference
Penner I, B xfc scher N, Dejung M, Freiwald A, Butter F, Plachter B. Subviral Dense Bodies of Human Cytomegalovirus Induce an Antiviral Type I Interferon Response. Cells. 2022;11: pubmed publisher
Leng K, Rose I, Kim H, Xia W, Romero Fernandez W, Rooney B, et al. CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states. Nat Neurosci. 2022;25:1528-1542 pubmed publisher
Popp M, Klippstein M, Lohneis P, Kalinski T, Li J, Quaas A, et al. Interferon-Induced Protein With Multiple Tetratricopeptide Repeats 3 Is Associated With Response to Chemotherapy and Recurrence but Not With Survival. Pancreas. 2020;49:1307-1314 pubmed publisher
Wang Z, Qin J, Zhao J, Li J, Li D, Popp M, et al. Inflammatory IFIT3 renders chemotherapy resistance by regulating post-translational modification of VDAC2 in pancreatic cancer. Theranostics. 2020;10:7178-7192 pubmed publisher
Fleith R, Mears H, Leong X, Sanford T, Emmott E, Graham S, et al. IFIT3 and IFIT2/3 promote IFIT1-mediated translation inhibition by enhancing binding to non-self RNA. Nucleic Acids Res. 2018;46:5269-5285 pubmed publisher

product information

Product Type :

Antibody

Product Name :

IFIT3 Polyclonal Antibody

Catalog # :

PA5-22230

Quantity :

100 uL

Price :

US 470.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Immunocytochemistry: 1:100-1:1,000, Immunohistochemistry (Paraffin): 1:100-1:1,000, Western Blot: 1:1,000-1:10,000

Species :

Human, Mouse

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exhibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2.

Immunogen :

Recombinant fragment corresponding to a region within amino acids 230 and 490 of IFIT3 (Uniprot ID#O14879)

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:100-1:1,000, Immunohistochemistry (Paraffin): 1:100-1:1,000, Western Blot: 1:1,000-1:10,000

Aliases :

cig41; CIG49; CIG-49; Garg49; GARG-49; Glucocorticoid-attenuated response gene 49 protein; Ifi49; IFI60; IFI-60K; IFIT3; IFIT-3; IFIT4; IFIT-4; interferon induced protein with tetratricopeptide repeats 3; interferon-induced 60 kDa protein; Interferon-induced protein with tetratricopeptide repeats 3; interferon-induced protein with tetratricopeptide repeats 4; interferon-stimulated protein 60; IRG2; Isg49; ISG60; ISG-60; P49; P60; retinoic acid-induced gene G protein; RIG-G; RP11-149I23.4