FIS1 Polyclonal Antibody | Invitrogen PA5-22142 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

FIS1 Polyclonal Antibody

catalog :

PA5-22142

quantity :

100 µL

price :

US 496.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 11

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:1000; fig 3	Mukherjee R, Chakrabarti O. Ubiquitin-mediated regulation of the E3 ligase GP78 by MGRN1 in trans affects mitochondrial homeostasis. J Cell Sci. 2016;129:757-73 pubmed publisher
	Fihurka O, Wang Y, Hong Y, Lin X, Shen N, Yang H, et al. Multi-Targeting Intranasal Nanoformulation as a Therapeutic for Alzheimer's Disease. Biomolecules. 2023;13: pubmed publisher
	Soundararajan R, Hern xe1 ndez Cuervo H, Stearns T, Griswold A, Patil S, Fukumoto J, et al. A-Kinase Anchor Protein 1 deficiency causes mitochondrial dysfunction in mouse model of hyperoxia induced acute lung injury. Front Pharmacol. 2022;13:980723 pubmed publisher
	Quiring L, Walter B, Lohaus N, Schwan D, Rech A, Dlugos A, et al. Characterisation of cold-induced mitochondrial fission in porcine aortic endothelial cells. Mol Med. 2022;28:13 pubmed publisher
	Chidipi B, Angulo M, Shah S, Rieser M, Ullah G, McDonald T, et al. The dynamin-related protein 1 is decreased and the mitochondrial network is altered in Friedreich's ataxia cardiomyopathy. Int J Biochem Cell Biol. 2022;143:106137 pubmed publisher
	Chidipi B, Shah S, Reiser M, Kanithi M, Garces A, Cha B, et al. All-Trans Retinoic Acid Increases DRP1 Levels and Promotes Mitochondrial Fission. Cells. 2021;10: pubmed publisher
	Portz P, Lee M. Changes in Drp1 Function and Mitochondrial Morphology Are Associated with the α-Synuclein Pathology in a Transgenic Mouse Model of Parkinson's Disease. Cells. 2021;10: pubmed publisher
	He M, Ma Y, Wang R, Zhang J, Jing L, Li P. Deletion of Mitochondrial Uncoupling Protein 2 Exacerbates Mitochondrial Damage in Mice Subjected to Cerebral Ischemia and Reperfusion Injury under both Normo- and Hyperglycemic Conditions. Int J Biol Sci. 2020;16:2788-2802 pubmed publisher
	Sanchez G, Chalmers S, Ahumada X, Montecinos L, Olmedo I, Eisner V, et al. Inhibition of chymotrypsin-like activity of the proteasome by ixazomib prevents mitochondrial dysfunction during myocardial ischemia. PLoS ONE. 2020;15:e0233591 pubmed publisher
	Ke M, Chong C, Zeng H, Huang M, Huang Z, Zhang K, et al. Azoramide protects iPSC-derived dopaminergic neurons with PLA2G6 D331Y mutation through restoring ER function and CREB signaling. Cell Death Dis. 2020;11:130 pubmed publisher
	Jean Beltran P, Cook K, Hashimoto Y, Galitzine C, Murray L, Vitek O, et al. Infection-Induced Peroxisome Biogenesis Is a Metabolic Strategy for Herpesvirus Replication. Cell Host Microbe. 2018;24:526-541.e7 pubmed publisher

product information

Product Type :

Antibody

Product Name :

FIS1 Polyclonal Antibody

Catalog # :

PA5-22142

Quantity :

100 µL

Price :

US 496.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: 1:100-1:2,000, Immunohistochemistry (Paraffin): 1:100-1:1,000, Western Blot: 1:500-1:20,000

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Description :

Fis1, a 17KDa integral membrane protein, is a novel member of mitochondrial fission machinery. It consists of a central leucine-zipper domain, a coiled-coil region, a tetratricopeptide repeat domain and a C-terminal transmembrane domain. It is a human orthologue of Fis1p (S.cerevisiae) and is localized in the outer mitochondrial membrane. Fis1 acts as a pro-apoptotic factor and plays a vital role in the regulation of mitochondrial fission. It interacts with DLP1 and Mdv1p and facilitates Dnm1p recruitment to the functional fission complex, thereby inducing apoptosis. Role of Fis1 has also been implicated in growth and division of peroxisomes. Loss of Fis1 inhibits apoptosis and results in elongation of mammalian mitochondria.

Immunogen :

Full-length human FIS1 recombinant protein

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:100-1:2,000, Immunohistochemistry (Paraffin): 1:100-1:1,000, Western Blot: 1:500-1:20,000

Aliases :

2010003O14Rik; CGI-135; Fis1; fis1 {ECO:0000250; FIS1 homolog; fission 1 (mitochondrial outer membrane) homolog; fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae); fission 1 (mitochondrial outer membrane) homolog (yeast); fission, mitochondrial 1; H_NH0132A01.6; hFis1; Mitochondrial fission 1 protein; mitochondrial fission molecule; rFis1; tetratricopeptide repeat domain 11; tetratricopeptide repeat protein 11; TPR repeat protein 11; TTC11; UniProtKB:Q9Y3D6}

more info or order :

Invitrogen product webpage