PSAT1 Polyclonal Antibody | Invitrogen PA5-22124 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PSAT1 Polyclonal Antibody

catalog :

PA5-22124

quantity :

100 uL

price :

US 514.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

citations: 16

Reference
Conger K, Chidley C, Ozgurses M, Zhao H, Kim Y, Semina S, et al. ASCT2 is the primary serine transporter in cancer cells. bioRxiv. 2023;: pubmed publisher
D Avola A, Legrave N, Tajan M, Chakravarty P, Shearer R, King H, et al. PHGDH is required for germinal center formation and is a therapeutic target in MYC-driven lymphoma. J Clin Invest. 2022;132: pubmed publisher
Choi B, Rawat V, H xf6 gstr xf6 m J, Burns P, Conger K, Ozgurses M, et al. Lineage-specific silencing of PSAT1 induces serine auxotrophy and sensitivity to dietary serine starvation in luminal breast tumors. Cell Rep. 2022;38:110278 pubmed publisher
Zhang Y, Yu H, Zhang J, Gao H, Wang S, Li S, et al. Cul4A-DDB1-mediated monoubiquitination of phosphoglycerate dehydrogenase promotes colorectal cancer metastasis via increased S-adenosylmethionine. J Clin Invest. 2021;131: pubmed publisher
Tajan M, Hennequart M, Cheung E, Zani F, Hock A, Legrave N, et al. Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy. Nat Commun. 2021;12:366 pubmed publisher
Elsaadi S, Steiro I, Abdollahi P, Vandsemb E, Yang R, Sl xf8 rdahl T, et al. Targeting phosphoglycerate dehydrogenase in multiple myeloma. Exp Hematol Oncol. 2021;10:3 pubmed publisher
Białopiotrowicz E, Noyszewska Kania M, Kachamakova Trojanowska N, Łoboda A, Cybulska M, Grochowska A, et al. Serine Biosynthesis Pathway Supports MYC-miR-494-EZH2 Feed-Forward Circuit Necessary to Maintain Metabolic and Epigenetic Reprogramming of Burkitt Lymphoma Cells. Cancers (Basel). 2020;12: pubmed publisher
Pathria G, Lee J, Hasnis E, Tandoc K, Scott D, Verma S, et al. Translational reprogramming marks adaptation to asparagine restriction in cancer. Nat Cell Biol. 2019;21:1590-1603 pubmed publisher
Selvarajah B, Azuelos I, Platè M, Guillotin D, Forty E, Contento G, et al. mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β1-induced collagen biosynthesis. Sci Signal. 2019;12: pubmed publisher
Lodovichi S, Mercatanti A, Cervelli T, Galli A. Computational analysis of data from a genome-wide screening identifies new PARP1 functional interactors as potential therapeutic targets. Oncotarget. 2019;10:2722-2737 pubmed publisher
Wang X, Min S, Liu H, Wu N, Liu X, Wang T, et al. Nf1 loss promotes Kras-driven lung adenocarcinoma and results in Psat1-mediated glutamate dependence. EMBO Mol Med. 2019;11: pubmed publisher
Meléndez Rodríguez F, Urrutia A, Lorendeau D, Rinaldi G, Roche O, Böğürcü Seidel N, et al. HIF1α Suppresses Tumor Cell Proliferation through Inhibition of Aspartate Biosynthesis. Cell Rep. 2019;26:2257-2265.e4 pubmed publisher
Ishida C, Zhang Y, Bianchetti E, Shu C, Nguyen T, Kleiner G, et al. Metabolic Reprogramming by Dual AKT/ERK Inhibition through Imipridones Elicits Unique Vulnerabilities in Glioblastoma. Clin Cancer Res. 2018;24:5392-5406 pubmed publisher
Svoboda L, Teh S, Sud S, Kerk S, Zebolsky A, Treichel S, et al. Menin regulates the serine biosynthetic pathway in Ewing sarcoma. J Pathol. 2018;245:324-336 pubmed publisher
Bellissimo T, Ganci F, Gallo E, Sacconi A, Tito C, De Angelis L, et al. Thymic Epithelial Tumors phenotype relies on miR-145-5p epigenetic regulation. Mol Cancer. 2017;16:88 pubmed publisher
DeNicola G, Chen P, Mullarky E, Sudderth J, Hu Z, Wu D, et al. NRF2 regulates serine biosynthesis in non-small cell lung cancer. Nat Genet. 2015;47:1475-81 pubmed publisher

product information

Product Type :

Antibody

Product Name :

PSAT1 Polyclonal Antibody

Catalog # :

PA5-22124

Quantity :

100 uL

Price :

US 514.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Immunocytochemistry: 1:100-1:1,000, Immunohistochemistry (Paraffin): 1:100-1:1,000, Western Blot: 1:500-1:3,000

Species :

Human, Mouse

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

The protein encoded by this gene is likely a phosphoserine aminotransferase, based on similarity to proteins in mouse, rabbit, and Drosophila. Alternative splicing of this gene results in two transcript variants encoding different isoforms.

Immunogen :

Recombinant fragment corresponding to a region within amino acids 48 and 328 of PSAT1 (Uniprot ID#Q9Y617)

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:100-1:1,000, Immunohistochemistry (Paraffin): 1:100-1:1,000, Western Blot: 1:500-1:3,000

Aliases :

D8Ertd814e; endometrial progesterone-induced protein; EPIP; NLS2; Phosphohydroxythreonine aminotransferase; phosphoserine aminotransferase; phosphoserine aminotransferase 1; PSA; Psa1; Psat; Psat1; PSATD