product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Klotho Polyclonal Antibody
catalog :
PA5-21078
quantity :
100 ug
price :
US 470.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section
more info or order :
Invitrogen product webpage
citations: 7
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; human; loading ...; fig 4b
  • western blot; human; loading ...; fig 4c
Mytych J, Wos I, Solek P, Koziorowski M. Protective role of klotho protein on epithelial cells upon co-culture with activated or senescent monocytes. Exp Cell Res. 2017;350:358-367 pubmed publisher
Solek P, Mytych J, Sujkowska E, Grzegorczyk M, Jasiewicz P, Sowa Kucma M, et al. Trade-offs between male fertility reduction and selected growth factors or the klotho response in a lipopolysaccharide-dependent mouse model. Toxicol Res. 2022;38:175-186 pubmed publisher
Suksridechacin N, Thongon N. Fibroblast growth factor-23 and parathyroid hormone suppress small intestinal magnesium absorption. Physiol Rep. 2022;10:e15247 pubmed publisher
Chang H, Peng K, Chan C, Sun C, Chen Y, Chang H, et al. FGF23 ameliorates ischemia-reperfusion induced acute kidney injury via modulation of endothelial progenitor cells: targeting SDF-1/CXCR4 signaling. Cell Death Dis. 2021;12:409 pubmed publisher
Mytych J, Sołek P, Będzińska A, Rusinek K, Warzybok A, Tabęcka Łonczyńska A, et al. Towards Age-Related Anti-Inflammatory Therapy: Klotho Suppresses Activation of ER and Golgi Stress Response in Senescent Monocytes. Cells. 2020;9: pubmed publisher
Morii K, Yamasaki S, Doi S, Irifuku T, Sasaki K, Doi T, et al. microRNA-200c regulates KLOTHO expression in human kidney cells under oxidative stress. PLoS ONE. 2019;14:e0218468 pubmed publisher
Delcroix V, Mauduit O, Tessier N, Montillaud A, Lesluyes T, Ducret T, et al. The Role of the Anti-Aging Protein Klotho in IGF-1 Signaling and Reticular Calcium Leak: Impact on the Chemosensitivity of Dedifferentiated Liposarcomas. Cancers (Basel). 2018;10: pubmed publisher
product information
Product Type :
Antibody
Product Name :
Klotho Polyclonal Antibody
Catalog # :
PA5-21078
Quantity :
100 ug
Price :
US 470.00
Clonality :
Polyclonal
Purity :
Antigen affinity chromatography
Host :
Rabbit
Reactivity :
Human, Mouse, Rat
Applications :
Immunohistochemistry (Paraffin): 2.5 ug/mL, Immunohistochemistry (PFA fixed): 20 ug/mL, Western Blot: 1-2 ug/mL
Species :
Human, Mouse, Rat
Isotype :
IgG
Storage :
Maintain refrigerated at 2-8 C for up to 3 months. For long term storage store at -20 C
Description :
KLOTHO is the systemic anti-aging hormone within the glycosidase1 superfamily. It encodes a type I membrane protein that is abundant in the kidney and brain. In mice, a deficiency in KLOTHO expression leads to various systemic phenotypes resembling human aging such as arteriosclerosis, osteoporosis, and skin atrophy together with growth retardation, short life-span and infertility. Transgenic mice overexpressing KLOTHO have an extended life span by inhibiting insulin/IGF1 signaling. KLOTHO is involved in the regulation of calcium/phosphorus homeostasis by inhibiting the synthesis of active vitamin D and identified as a potential tumor suppressor.
Immunogen :
A 17 amino acid peptide near the center of human KLOTHO.
Format :
Liquid
Applications w/Dilutions :
Immunohistochemistry (Paraffin): 2.5 ug/mL, Immunohistochemistry (PFA fixed): 20 ug/mL, Western Blot: 1-2 ug/mL
Aliases :
alpha-kl; HFTC3; Kl; Klotho; Klotho peptide; secreted form of Klotho protein
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA