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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
PRDM16 Polyclonal Antibody
catalog :
PA5-20872
quantity :
100 ug
price :
US 470.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry
more info or order :
Invitrogen product webpage
citations: 18
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:1000; loading ...; fig 2e
Zou T, Chen D, Yang Q, Wang B, Zhu M, Nathanielsz P, et al. Resveratrol supplementation of high-fat diet-fed pregnant mice promotes brown and beige adipocyte development and prevents obesity in male offspring. J Physiol. 2017;595:1547-1562 pubmed publisher
Chae S, Du M, Son J, Zhu M. Exercise improves homeostasis of the intestinal epithelium by activation of apelin receptor-AMP-activated protein kinase signalling. J Physiol. 2023;601:2371-2389 pubmed publisher
Chae S, Son J, de Avila J, Du M, Zhu M. Maternal exercise improves epithelial development of fetal intestine by enhancing apelin signaling and oxidative metabolism. Am J Physiol Regul Integr Comp Physiol. 2022;323:R728-R738 pubmed publisher
Xue L, Sun J, Liu J, Hu C, Wu D, Nie C, et al. Maternal secretin ameliorates obesity by promoting white adipose tissue browning in offspring. EMBO Rep. 2022;23:e54132 pubmed publisher
Chae S, Son J, Zhao L, Gao Y, Liu X, Marie de Avila J, et al. Exerkine apelin reverses obesity-associated placental dysfunction by accelerating mitochondrial biogenesis in mice. Am J Physiol Endocrinol Metab. 2022;322:E467-E479 pubmed publisher
Chen Y, Yang Q, Hu Y, Liu X, de Avila J, Zhu M, et al. Imprinted lncRNA Dio3os preprograms intergenerational brown fat development and obesity resistance. Nat Commun. 2021;12:6845 pubmed publisher
Cao Y, Deng B, Zhang S, Gao H, Song P, Zhang J, et al. Astragalus polysaccharide regulates brown adipogenic differentiation through miR-1258-5p-modulated cut-like homeobox 1 expression. Acta Biochim Biophys Sin (Shanghai). 2021;53:1713-1722 pubmed publisher
Matrone G, Xia B, Chen K, Denvir M, Baker A, Cooke J. Fli1+ cells transcriptional analysis reveals an Lmo2-Prdm16 axis in angiogenesis. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
Gao X, Deng B, Li X, Wang Y, Zhang J, Hao X, et al. Melatonin Regulates Differentiation of Sheep Brown Adipocyte Precursor Cells Via AMP-Activated Protein Kinase. Front Vet Sci. 2021;8:661773 pubmed publisher
Chen Y, Hu Y, Yang Q, Liu X, Son J, de Avila J, et al. Embryonic exposure to hyper glucocorticoids suppresses brown fat development and thermogenesis via REDD1. Sci Bull (Beijing). 2021;66:478-489 pubmed publisher
Son J, Zhao L, Chen Y, Chen K, Chae S, de Avila J, et al. Maternal exercise via exerkine apelin enhances brown adipogenesis and prevents metabolic dysfunction in offspring mice. Sci Adv. 2020;6:eaaz0359 pubmed publisher
Tian Q, Zhao J, Yang Q, Wang B, Deavila J, Zhu M, et al. Dietary alpha-ketoglutarate promotes beige adipogenesis and prevents obesity in middle-aged mice. Aging Cell. 2020;19:e13059 pubmed publisher
Lau W, Noruddin N, Ariffin A, Mahmud M, Noor M, Amanah A, et al. Novel discovery of Averrhoa bilimbi ethanolic leaf extract in the stimulation of brown fat differentiation program in combating diet-induced obesity. BMC Complement Altern Med. 2019;19:243 pubmed publisher
Clayton Z, McCurdy C. Short-term thermoneutral housing alters glucose metabolism and markers of adipose tissue browning in response to a high-fat diet in lean mice. Am J Physiol Regul Integr Comp Physiol. 2018;315:R627-R637 pubmed publisher
Than A, Xu S, Li R, Leow M, Sun L, Chen P. Angiotensin type 2 receptor activation promotes browning of white adipose tissue and brown adipogenesis. Signal Transduct Target Ther. 2017;2:17022 pubmed publisher
Wang B, Zhang F, Zhang H, Wang Z, Ma Y, Zhu M, et al. Alcohol intake aggravates adipose browning and muscle atrophy in cancer-associated cachexia. Oncotarget. 2017;8:100411-100420 pubmed publisher
Wang B, Fu X, Liang X, Deavila J, Wang Z, Zhao L, et al. Retinoic acid induces white adipose tissue browning by increasing adipose vascularity and inducing beige adipogenesis of PDGFRα+ adipose progenitors. Cell Discov. 2017;3:17036 pubmed publisher
Than A, He H, Chua S, Xu D, Sun L, Leow M, et al. Apelin Enhances Brown Adipogenesis and Browning of White Adipocytes. J Biol Chem. 2015;290:14679-91 pubmed publisher
product information
Product Type :
Antibody
Product Name :
PRDM16 Polyclonal Antibody
Catalog # :
PA5-20872
Quantity :
100 ug
Price :
US 470.00
Clonality :
Polyclonal
Purity :
Antigen affinity chromatography
Host :
Rabbit
Reactivity :
Human, Mouse
Applications :
Immunocytochemistry: 20 ug/mL, Immunohistochemistry: 2 ug/mL, Western Blot: 1.0 ug/mL
Species :
Human, Mouse
Isotype :
IgG
Storage :
4 C
Description :
PRDM16 is a zinc finger transcription factor and contains an N-terminal PR domain. The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36, q21)-positive MDS/AML. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Recent studies have shown that PRDM16 normally acts as a Smad3 binding protein that may be important for the development of orofacial structures through modulation of the TGF-beta signaling pathway. Other experiments have indicated that PRDM16 controls a bidirectional cell fate switch between skeletal myoblasts and brown fat cells.
Immunogen :
A 17 amino acid peptide from near the carboxy terminus of human PRDM16.
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: 20 ug/mL, Immunohistochemistry: 2 ug/mL, Western Blot: 1.0 ug/mL
Aliases :
5730557K01Rik; CMD1LL; csp1; Histone-lysine N-methyltransferase PRDM16; Kiaa1675; line 27; LVNC8; MDS1/EVI1-like gene 1; MEL1; PFM13; PR domain 16; PR domain containing 16; PR domain zinc finger protein 16; PR domain-containing protein 16; Prdm16; Transcription factor MEL1
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA