PLEKHM2 Polyclonal Antibody | Invitrogen PA5-20850 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PLEKHM2 Polyclonal Antibody

catalog :

PA5-20850

quantity :

100 ug

price :

US 470.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry

citations: 2

Reference
Roney J, Li S, Farfel Becker T, Huang N, Sun T, Xie Y, et al. Lipid-mediated motor-adaptor sequestration impairs axonal lysosome delivery leading to autophagic stress and dystrophy in Niemann-Pick type C. Dev Cell. 2021;56:1452-1468.e8 pubmed publisher
Muhammad E, Levitas A, Singh S, Braiman A, Ofir R, Etzion S, et al. PLEKHM2 mutation leads to abnormal localization of lysosomes, impaired autophagy flux and associates with recessive dilated cardiomyopathy and left ventricular noncompaction. Hum Mol Genet. 2015;24:7227-40 pubmed publisher

product information

Product Type :

Antibody

Product Name :

PLEKHM2 Polyclonal Antibody

Catalog # :

PA5-20850

Quantity :

100 ug

Price :

US 470.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: 20 ug/mL, Immunohistochemistry: 5 ug/mL, Western Blot: 0.5 ug/mL

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

Maintain refrigerated at 2-8 C for up to 3 months. For long term storage store at -20 C

Description :

PLEKHM2, also known as SKIP, is a member of the M family of Pleckstrin homology domain-containing proteins. While little is known of PLEKHM2, a recent study examining differential gene expression in human hematopoietic stem cells has shown it to be specifically expressed in stem cells, suggesting that PLEKHM2 may play a role in erythroid commitment and development. Other studies have shown that PLEKHM2 is required for interaction with the Salmonella virulence factor SifA for Salmonella pathogenesis, suggesting that PLEKHM2 has cellular roles other than in the developing embryo.

Immunogen :

A 17 amino acid peptide from near the carboxy terminus of human PLEKHM2.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 20 ug/mL, Immunohistochemistry: 5 ug/mL, Western Blot: 0.5 ug/mL

Aliases :

2310034J19Rik; AI854247; KIAA0842; mKIAA0842; novel RUN and PH domain-containing protein; PH domain-containing family M member 2; pleckstrin homology and RUN domain containing M2; pleckstrin homology domain containing, family M (with RUN domain) member 2; pleckstrin homology domain-containing family M member 2; Plekhm2; RP11-169K16.1; Salmonella-induced filaments A and kinesin-interacting protein; SifA (Salmonella-induced filaments A) and kinesin-interacting protein; sifA and kinesin-interacting protein; SKIP