SKA2 Polyclonal Antibody | Invitrogen PA5-20818 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

SKA2 Polyclonal Antibody

catalog :

PA5-20818

quantity :

100 ug

price :

US 464.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot

citations: 2

Reference
Xia X, Tao C, Du K, Meng P, Hu L, Cheng D, et al. SKA2-mediated transcriptional downregulation of the key enzyme of CoQ10 biosynthesis PDSS2 in lung cancer cells. J Cancer. 2023;14:379-392 pubmed publisher
Sun Y, Xu D, Zhang C, Wang Y, Zhang L, Qiao D, et al. HEDGEHOG/GLI Modulates the PRR11-SKA2 Bidirectional Transcription Unit in Lung Squamous Cell Carcinomas. Genes (Basel). 2021;12: pubmed publisher

product information

Product Type :

Antibody

Product Name :

SKA2 Polyclonal Antibody

Catalog # :

PA5-20818

Quantity :

100 ug

Price :

US 464.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Western Blot: 0.5-1 ug/mL

Species :

Human, Mouse

Isotype :

IgG

Storage :

Maintain refrigerated at 2-8 C for up to 3 months. For long term storage store at -20 C

Description :

Upon entry into mitosis, the cell’s microtubule (MT) network forms the mitotic spindle, allowing the segregation of paired chromosomes. Proteinaceous structures on centromeric chromatin termed kinetochores (KT) are essential for the proper attachment of the chromosomes to the spindle MTs. A recently discovered spindle and kinetochore complex, comprised of proteins SKA1, SKA2, and SKA3, has been found to be required for stable KT-MT interactions and timely anaphase onset. Depletion of either SKA1 or SKA2 by siRNA results in the loss of both proteins from the KT, but does not impact overall KT structure. Cells depleted of the SKA complex undergo a prolonged checkpoint-dependent delay in a metaphase-like state, indicating the importance of the SKA complex in the maintenance of the metaphase plate and spindle checkpoint silencing. SKA2 has also been shown to interact with glucocorticoid receptors and to be involved in glucocorticoid signaling and cell proliferation.

Immunogen :

A 15 amino acid peptide from near the amino terminus of human SKA2.

Format :

Liquid

Applications w/Dilutions :

Western Blot: 0.5-1 ug/mL

Aliases :

1110001A07Rik; C78640; FAM33A; family with sequence similarity 33, member A; Protein FAM33A; RGD1307084; Ska2; spindle and kinetochore associated complex subunit 2; spindle and kinetochore-associated protein 2; spindle and KT (kinetochore) associated 2